Intraoperative presacral electron boost following preoperative chemoradiation in T3–4Nx rectal cancer: initial local effects and clinical outcome analysis

Value of Intraoperative Radiotherapy in Locally Advanced Rectal Cancer

“…28 Previous studies have demonstrated that IORT achieves good local control and high survival rates in primary locally advanced rectal cancer. 7,10,11,21,[29][30][31][32] Most of the results reported regarding IORT in rectal cancer originate from a few centers, and randomized trials are lacking. In the present study, IORT improves the five-year local control rate in patients with an incomplete resection to 58 percent compared with 0 percent in patients who did not receive IORT.…”

“…21,31,38 Significantly important prognostic factors for overall survival are completeness of resection and negative lymph node status. In the literature, these are known prognostic factors, but other factors, such as extent of resection and fixation of tumor, also are reported.…”

The predictive value of 18F-FDG PET/CT for assessing pathological response and survival in locally advanced rectal cancer after neoadjuvant radiochemotherapy

“…Neoadjuvant treatment is intended to reduce the risk of local recurrence as well as to downsize/downstage the tumour, making successful conservative surgery more likely and consequently improving the patient's quality of life [5][6][7][8][9][10][11][12]. Unfortunately, not all patients benefit equally from preoperative radiochemotherapy (RCT) because tumour response is very heterogeneous, ranging from complete remission (12 -27 % of patients) to total resistance [13,14]. Therefore, accurate assessment of response to preoperative treatment could be of great value for "tailoring" the neoadjuvant regimen as well as the surgical approach to the individual patient [15,16].…”

Laparoscopic abdominoperineal resection with intraoperative radiotherapy for locally advanced low rectal cancer

“…Local control is 8% higher when using IORT (ref. 13,[16][17][18][19][20] ). Roeder and Krempien actually report up to 18% lower incidence of local recurrence in the area of applied IORT (ref.…”