Intraoperative sponge 5-flourouracil to reduce postoperative scarring in strabismus surgery

Mora, Justin; Sprunger, Derek T.; Helveston, Eugene M.; Evan, Andrew P.

doi:10.1016/s1091-8531(97)90005-7

Cited by 46 publications

(47 citation statements)

References 13 publications

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“…Such adhesions may prevent the normal function of an extraocular muscle and render strabismus surgery ineffective. 6,7 Once the adhesions develop, it is difficult to reverse their effects. The development of secondary strabismus caused by scars can vary from a few months after surgery to several years later.…”

Section: Discussionmentioning

confidence: 99%

“…Experimental studies in which the antimetabolites mitomycin C and 5-fluorouracil were used have shown positive results in decreasing adhesion formation. 5,6 However, these agents are known to decrease vascularity and are also believed to increase the risk of anterior segment ischemia in patients who have undergone multiple strabismus surgeries. 6 Amniotic membrane transplantation has been used to treat such cicatricial ocular surface disorders as StevensJohnson syndrome, alkali burn, and ocular cicatricial pemphigoid.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 However, these agents are known to decrease vascularity and are also believed to increase the risk of anterior segment ischemia in patients who have undergone multiple strabismus surgeries. 6 Amniotic membrane transplantation has been used to treat such cicatricial ocular surface disorders as StevensJohnson syndrome, alkali burn, and ocular cicatricial pemphigoid. The benefits of amniotic membrane include suppression of recurrent subconjunctival fibrosis after symblepharonlysis.…”

Section: Discussionmentioning

confidence: 99%

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The use of amniotic membrane in reducing adhesions after strabismus surgery

Sheha

Casas

Hayashida

2009

Journal of American Association for Pediatric Ophthalmology and

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The use of amniotic membrane in reducing adhesions after strabismus surgery

Sheha

Casas

Hayashida

2009

Journal of American Association for Pediatric Ophthalmology and

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“…Experimental studies employing antimetabolites mitomycin C and 5-fluorouracil have shown positive results in decreasing adhesion formation. 9,16 However, these agents have the potential risk of serious side effects. Antimetabolites are known to cause severe corneal and scleral complications when used in glaucoma and pterygium surgeries.…”

Section: Discussionmentioning

confidence: 99%

The effect of the cell-derived extracellular matrix membrane on wound adhesions in rabbit strabismus surgery

Yang

Heo

Lee

et al. 2014

Tissue Eng Regen Med

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The cell-derived extracellular matrix (ECM) membrane is a bio-absorbable membrane composed of aseptic ECM obtained from swine knee chondrocyte. The purpose of our study was to evaluate the inhibitory effect of the cell-derived ECM membrane in postoperative adhesion following strabismus surgery on rabbit eyes. Twenty four adult male New Zealand albino rabbits were used. Each rabbit has undergone 3 mm resection of the superior rectus muscle in both eyes. The cell-derived ECM membrane was applied between the conjunctiva and superior rectus muscle only to right eye in each rabbit. The eyes were divided into a surgery-ECM group and a surgery-no ECM group. The rabbits were sacrificed at 2, 4, and 6 weeks after the surgery. Each time, 16 eyes of 8 rabbits were enucleated to observe the adhesion in muscle and adjacent tissue grossly by blunt dissection. Then, histopathological sections were analyzed for inflammation and fibrosis by staining with hematoxylin-eosin and Masson trichrome, respectively. Inflammation and fibrosis were graded on a scale of 0 to 4. A researcher was blind to the experiments performed all the examinations. Comparing with the surgery-no ECM group, there was no significant difference with regard to inflammation at the area of superior rectus muscle resection at 2, 4, and 6 postoperative weeks (p = 0.52, p = 0.55, p = 0.82). However, a significant reduction in the degree of adhesion (p = 0.01, p = 0.03, p = 0.04) as well as decreased fibrosis (p = 0.04, p = 0.03, p = 0.02) between muscle and conjunctiva after strabismus surgery was observed in all surgery-ECM groups. The current results demonstrated that the cell-derived ECM membrane could inhibit the formation of postoperative adhesion and fibrosis between conjunctiva and muscle. The authors concluded that the use of ECM membrane could reduce postoperative adhesion around surgical area after strabismus surgery in rabbits.

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“…Restrictions usually develop after excessive resections, intraconal fat violation or scar tissue formation, which result in postoperative adhesions [2]. Various approaches have been used to prevent the formation of postsurgical adhesions, including polyamide 6.6 (Supramid; Jackson, Alexandria, VA, USA), silicone sleeves, polyglactin 910 mesh, polypeptide sleeves, sodium hyaluronate, steroids, mitomycin C, 5 fluorouracil and Seprafilm (Genzyme, Cambridge, MA, USA) [3][4][5][6][7][8][9]. However, none of these approaches is widely used because of associated complications, unavailability or inconsistent results.…”

Section: Introductionmentioning

confidence: 99%