2019
DOI: 10.1002/lt.25486
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Intraoperative Versus Extended Antibiotic Prophylaxis in Liver Transplant Surgery: A Randomized Controlled Pilot Trial

Abstract: The appropriate duration of surgical antibiotic prophylaxis in orthotopic liver transplantation (OLT) in the presence of significant iatrogenic immunosuppression is unclear. We hypothesized that 72 hours of perioperative antibiotic prophylaxis would decrease rates of surgical site infection (SSI) in OLT patients when compared with intraoperative antibiotic prophylaxis alone. OLT recipients were randomized to receive either intraoperative antibiotics only (short antibiotics [SAs]) or 72 hours of perioperative a… Show more

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Cited by 43 publications
(49 citation statements)
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“…Allocation concealment was judged to be low risk in one study (Berry 2019). The risk of bias was unclear in the remaining seven studies.…”
Section: Allocation Concealmentmentioning
confidence: 99%
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“…Allocation concealment was judged to be low risk in one study (Berry 2019). The risk of bias was unclear in the remaining seven studies.…”
Section: Allocation Concealmentmentioning
confidence: 99%
“…Eight studies (718 randomised participants) were included in this review (Berry 2019;Cohen 1988;Evans 1988;Robles 1990;Townsend 1980;Wilms 1986).…”
Section: Included Studiesmentioning
confidence: 99%
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“…On the basis of the published literature demonstrating high SSI rates after LT and the perception that extended SAP will minimize risks, continuing SAP after LT is a common practice, although no studies have validated it. We applaud Berry et al for exploring this topic in a pilot study published in this issue of Liver Transplantation …”
mentioning
confidence: 99%
“…We applaud Berry et al for exploring this topic in a pilot study published in this issue of Liver Transplantation. (5) This was a single-center, open-label, randomized controlled study comparing SSI rates in 2 SAP groups: short antibiotics (SAs) and extended antibiotics (EAs) with 51 first-time, nonhospitalized LT candidates enrolled in each group. Patients in both groups received 1 dose of intravenous antibacterials 30 minutes prior to incision.…”
mentioning
confidence: 99%