Intrapericardial Ectopic Thyroid Carcinoma in a Cat

Knowles, Susan; Uhl, Elizabeth W.; Blás-Machado, Uriel; Butler, Abigail M.

doi:10.1177/104063871002200632

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…In addition, additional ectopic thyroid tissue may be present anywhere from the base of the tongue to within the thoracic cavity (Knowles et al, 2010;Reed et al, 2011). In addition, additional ectopic thyroid tissue may be present anywhere from the base of the tongue to within the thoracic cavity (Knowles et al, 2010;Reed et al, 2011).…”

Section: Determine Presence Of Mediastinal or Ectopic Thyroid Tissuementioning

confidence: 99%

Feline Hyperthyroidism

Scott‐Moncrieff¹

2015

Canine and Feline Endocrinology

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Section: Determine Presence Of Mediastinal or Ectopic Thyroid Tissuementioning

confidence: 99%

Feline Hyperthyroidism

Scott‐Moncrieff¹

2015

Canine and Feline Endocrinology

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“…8 – 10 Reports of non-lymphomatous pericardial neoplasms include intrapericardial ectopic thyroid carcinoma, primary cardiac rhabdomyosarcoma, chemodectoma, mesothelioma, primary and metastatic hemangiosarcoma, fibrosarcoma, multiple myeloma, carcinoid carcinomatosis, aortic body carcinoma, multiple metastatic carcinoma and primary myocardial sarcoma. 5 , 6 , 8 , 11 – 13 …”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10] Reports of non-lymphomatous pericardial neoplasms include intrapericardial ectopic thyroid carcinoma, primary cardiac rhabdomyosarcoma, chemodectoma, mesothelioma, primary and metastatic hemangiosarcoma, fibrosarcoma, multiple myeloma, carcinoid carcinomatosis, aortic body carcinoma, multiple metastatic carcinoma and primary myocardial sarcoma. 5,6,8,[11][12][13] Undifferentiated pleomorphic sarcoma (UPS), previously referred to as malignant fibrous histiocytoma, is a mesenchymal neoplasm that has been well documented in human medicine. Tumors classified as UPS have a pleomorphic spindle cell population and are characterized by the absence of an identifiable line of differentiation either morphologically or immunohistochemically.…”

Section: Discussionmentioning

confidence: 99%

Pericardial effusion secondary to epicardial undifferentiated pleomorphic sarcoma in a young cat

Stone

Davies²,

Kridel

2023

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 6.4 kg 3-year-old male neutered indoor–outdoor domestic shorthair cat was referred for further evaluation of non-resolving lethargy and hyporexia of 4 days’ duration. Physical examination identified tachypnea with mild respiratory effort and muffled lung sounds bilaterally. Point-of-care ultrasound revealed a large volume of pleural and pericardial effusion (PCE), which was confirmed by thoracic radiography. Echocardiogram indicated normal cardiac function but revealed a mass-like structure along the left epicardium within the pericardial space. After 72 hours in hospital, re-evaluation via echocardiogram showed the epicardial mass lesion to have doubled in size and with apparent extension to involve the pericardium. The patient was hospitalized for 72 h of supportive care and intervention, including therapeutic pericardiocentesis, bilateral thoracocentesis, thoracic and cardiac imaging and infectious disease testing. On the third day of hospitalization, the patient developed cardiac tamponade. Further workup was discussed, including CT and subtotal pericardiectomy with biopsy, but the cat was euthanized due to clinical decline and rapid re-accumulation of effusion. Post-mortem histopathologic evaluation diagnosed an epicardial pleomorphic sarcoma, exclusive of mesothelioma or histiocytic sarcoma on immunohistochemistry (IHC). Relevance and novel information This report describes a case of epicardial undifferentiated pleomorphic sarcoma (UPS) in a young cat presenting with pleural and PCE. Pleomorphic sarcoma is a rarely reported mesenchymal neoplasia in the feline patient and has thus far primarily been identified in peripheral soft tissue structures. IHC is key to the correct histopathologic diagnosis. To our knowledge, epicardial UPS has not been previously reported in a cat.

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“…In addition, as the embryology of C‐cells differs from that of the thyroid follicular cell, it cannot be expected that C‐cells would also migrate to ectopic sites . In support of that, ectopic thyroid tissue characteristically shows negative immunostaining for calcitonin, and medullary thyroid tumors arising in ectopic sites have not been described in dogs . Similarly, in human patients, only a single case report of medullary carcinoma arising in an ectopic site has been reported, although ectopic thyroid disease is not uncommon, with over 500 reported cases described …”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Treatment Outcomes of 41 Dogs with Sublingual Ectopic Thyroid Neoplasia

Broome¹,

Peterson²,

Walker³

2014

Veterinary Internal Medicne

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BackgroundThyroid neoplasia is common in dogs, but there are few reports of dogs with ectopic, sublingual thyroid tumors.ObjectivesTo describe clinical features and outcomes of dogs with ectopic, sublingual thyroid neoplasia.AnimalsFive hundred and forty‐four dogs with thyroid neoplasia.MethodsThis retrospective study reviewed the medical records of dogs referred for thyroid neoplasia between 1995 and 2013. Data extracted included signalment, extent of thyroid disease (eutopic or ectopic; metastasis), serum thyroxine (T4) concentration, treatment, and survival.ResultsOf 544 dogs with thyroid neoplasia, 41 (7.5%) dogs had ectopic sublingual thyroid tumors. The clinical features of these 41 dogs were similar to the cohort group of 503 dogs with eutopic or ectopic mediastinal thyroid tumors, but dogs with sublingual tumors were younger and less likely to have metastatic disease (15% versus 30%, P < .05). Of the 41 dogs, 28 received treatment: 21 with surgery (which included partial hyoidectomy in 13), 7 with radioiodine alone, and 13 with surgery followed by administration of radioiodine. Overall median survival was 562 days (range, 1‐1,850 days).Conclusions and Clinical ImportanceWhen compared with eutopic thyroid carcinomas, ectopic sublingual thyroid tumors generally have a less aggressive biologic behavior. Many dogs have prolonged survival, even without treatment, although death because of local tumor invasiveness or metastasis can develop in some dogs. Surgical thyroidectomy, including partial hyoidectomy, is generally effective for control of local disease. Administration of radioiodine, alone or in combination with surgical treatment, is recommended for multifocal disease or metastasis.

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Intrapericardial Ectopic Thyroid Carcinoma in a Cat

Cited by 8 publications

References 7 publications

Feline Hyperthyroidism

Feline Hyperthyroidism

Pericardial effusion secondary to epicardial undifferentiated pleomorphic sarcoma in a young cat

Clinical Features and Treatment Outcomes of 41 Dogs with Sublingual Ectopic Thyroid Neoplasia

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