Intrapleural Fibrinolysis in Post-tubercular Loculated Pleural Effusions at a Tertiary-Care Respiratory Center: An Uncontrolled Blinded Before-After Intervention Study

Narayanan, Sheshadri; Bhattacharyya, Debajyoti; Khan, Inam Danish; Prasad, V. Devi; Kotaru, Arun; Vardhan, Vasu; Pandya, Kapil

doi:10.15171/hpr.2018.12

Cited by 2 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean FVC before IPFT was 46% with a standard deviation of 11. The mean FVC post IPFT showed an increase of 46% to 70% which is statistically significant (P<0.05) and were comparable to previous study 12 (Table 3).…”

Section: Discussionsupporting

confidence: 89%

“…The mean amount of intrapleural fluid present after administration of Streptokinase was 57.84ml with a standard deviation of 53.14 (Table 3), similar findings were reported in earlier study. 12 There is significant difference between mean amount of intrapleural fluid before and after IPFT. Thus, the use of IPFT with Streptokinase in loculated pleural effusion results in statistically significant reduction in the residual amount of intra pleural fluid (p value <0.001).…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Outcome of intrapleural fibrinolytic therapy with streptokinase in loculated pleural effusion patients- An experience from zonal hospital of Eastern India

Shukla¹,

Singh²,

Arora³

et al. 2020

PJMS

View full text Add to dashboard Cite

Background: Loculated pleural effusion is one of the most common clinical entities which are usually caused by empyema, tubercular pleural effusion, malignancy, and hemothorax. The role of Intra-pleural Fibrinolytic Therapy (IPFT) with various fibrinolytics has been studied, however its clinical, radiological and functional outcomes are not assessed completely. Objective : This is a pre and post intervention study conducted at tertiary care hospital to assess the role of IPFT with streptokinase in patients with loculated pleural effusion. Results: 102 patients underwent IPFT with streptokinase. Out of 102 patients, 84 patient were male and 18 were females. Main preprocedure diagnosis were tuberculosis (n=70), pneumonia (n=21) and malignancy (n=11). The patients were subdivided into three groups based on sonologically assessed amount of intrapleural fluid -Group 1 (<100ml), Group 2 (100-200ml) and Group 3 (>200ml). During pre and post IPFT procedure the number of patients identified in group 1 were 30 and 80, group 2 were 40 and 22, group 3 were 32 and none respectively. The mean residual pleural fluid drained before and after IPFT were 190.80ml and 57.84ml (p value<0.001), which had statistically significant reduction after IPFT. Mean FVC before and after IPFT were 46.43% and 69.56% (p value<0.05). Chest x-ray resolution was observed in 80 of the 102 patients with postprocedure IPFT (p value<0.05). Adverse effects noticed were chest pain, fever, tachycardia and bleeding. However no major bleeding was observed. Conclusion: IPFT with streptokinase is a safe option in loculated pleural effusion with no major adverse effects.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 93%

Outcome of intrapleural fibrinolytic therapy with streptokinase in loculated pleural effusion patients- An experience from zonal hospital of Eastern India

Shukla¹,

Singh²,

Arora³

et al. 2020

PJMS

View full text Add to dashboard Cite

show abstract

“…The usefulness of urokinase as an intra-pleural fibrinolytic drug in the treatment of patients with loculated pleural effusion has been investigated. The presence of pleural fluid despite a radiologically verified properly positioned ICD can indicate numerous locules in the pleural cavity or tube obstruction due to increased fluid viscosity [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Physical Therapy Rehabilitation for a Chronic Alcoholic Patient With Loculated Pleural Effusion

Tiwari¹,

Kumbhare²,

Walke³

2022

Cureus

View full text Add to dashboard Cite

Pleural effusion is the accumulation of extra fluid between the layers of the pleura outside the lungs, also known as water on the lungs. Pleura are thin membranes that lubricate and aid breathing by lining the lungs and the inside of the chest cavity. The pleural space typically contains only a few teaspoons of watery fluid, which enables the lungs to move easily inside the chest cavity when breathing. Several barriers limited the patient's capacity to carry out daily activities successfully and efficiently. Loculated effusions are most frequently associated with diseases such as empyema, hemothorax, or tuberculosis that result in severe pleural inflammation. Hence, a physiotherapy program is started to help improve the patient's symptoms. A 59-year-old male presented to the hospital with the chief complaint of left-sided chest pain, fever, and breathlessness. On the Modified Medical Research Council dyspnea scale, breathlessness was grade 3.

show abstract

Intrapleural Fibrinolysis in Post-tubercular Loculated Pleural Effusions at a Tertiary-Care Respiratory Center: An Uncontrolled Blinded Before-After Intervention Study

Cited by 2 publications

References 17 publications

Outcome of intrapleural fibrinolytic therapy with streptokinase in loculated pleural effusion patients- An experience from zonal hospital of Eastern India

Outcome of intrapleural fibrinolytic therapy with streptokinase in loculated pleural effusion patients- An experience from zonal hospital of Eastern India

Physical Therapy Rehabilitation for a Chronic Alcoholic Patient With Loculated Pleural Effusion

Contact Info

Product

Resources

About