Intrarectally administered polaprezinc attenuates the development of dextran sodium sulfate‑induced ulcerative colitis in mice

Abstract

/kg). After the animals were sacrificed, blood was collected and the serum levels of NF-κB and tumor necrosis factor-α (TNF-α) were measured. Changes in histology were observed by light microscopy. The protein levels of AKT, phosphorylated AKT and heat shock protein 70 (HSP70) were determined by western blot analysis. The results suggested that PZ reduced the DSS-induced increase in the inflammatory proteins TNF-α and NF-κB in the UC model. The high-dose of PZ also increased the HSP70 protein level, inhibited AKT phosphorylation in a DSS-induced UC animal model, and decreased white blood cell and neutrophil % counts compared to levels in an untreated DSS control group. Histopathology indicated that the mice of the DSS model group had irregular colonic villi, a large number of inflammatory cells and mucosal damage, whereas mice of the group treated with PZ had small intestinal villus morphology and their villi showed signs of recovery from the damage of UC. The results of the present study indicated that PZ significantly alleviates DSS-induced UC in mice, relieves diarrhea, and inhibits the phosphorylation of inflammatory factors and the inflammatory AKT signaling pathway.

Trypanosoma cruzi iron superoxide dismutases: insights from phylogenetics to chemotherapeutic target assessment

“…Polaprezinc is a chelated form of zinc and L -carnosine that shows therapeutic activity for the treatment of pressure ulcers and other intestinal lesions [ 61 , 62 ], is used in cancer chemotherapy [ 63 , 64 ], presents therapeutic effects on cardiac function [ 65 ] and has a protective effect against respiratory diseases [ 66 ].…”

Exploring the Common Genetic Signature and Molecular Mechanisms Between Gastritis and Gastric Cancer: A bioinformatics-coupled Network Pharmacology Analysis

“…However, carnosine has great potential in protecting the gastrointestinal mucosa and preventing the development of GC. Polaprezinc, a chelating compound containing L-carnosine and zinc, attenuated the development of dextran sodium sulfate-induced ulcerative colitis in mice [50]. Polaprezinc inhibited the proliferation of human GC SGC-7901 cells through the mitochondrial respiratory and glycolytic pathways and decreased the expression of mitochondrial PHB-1 [51,52].…”

Recent advances on polaprezinc for medical use (Review)

“…In 2016, a related patent was applied for in China. The subjects of the application and authorization were relatively similar, in terms of compounds, preparation methods and application patents (16)(17)(18).…”