Abstract. We study the combined effects of seasonal trends and diseases on the extinction and persistence of discretely reproducing populations. We introduce the epidemic threshold parameter, R 0 , for predicting disease dynamics in periodic environments. Typically, in periodic environments, R 0 > 1 implies disease persistence on a cyclic attractor, while R 0 < 1 implies disease extinction. We also explore the relationship between the demographic equation and the epidemic process. In particular, we show that in periodic environments, it is possible for the infective population to be on a chaotic attractor while the demographic dynamics is nonchaotic. 1. Introduction. The complexities of a periodic environment can significantly affect the regulation of species [26]. In periodic environments, population sizes are often either enhanced via resonance or diminished via attenuance [5,10,11,13,14,15,16,17,18,19,20,23,24,25,30,31,32,33,34,35,37,38,45,48,50] [37,38], and others have studied the effects of periodic environments on ecological models without explicit disease dynamics [46].In this paper, we focus on the impact of seasonal factors on a discrete-time SIS (susceptible-infected-susceptible) epidemic model. The model reduces to the SIS epidemic model of Castillo-Chavez and Yakubu when the environment is constant (nonperiodic) [7,8,9]. To understand the impact of seasonality and disease on life-history outcomes, we study the long-term dynamics of our model under specific functional forms for the periodic recruitment function. The periodic , the periodic constant, and the periodic Malthus (geometric growth) models are the periodic recruitment functions for this study [7,8,9].We assume that a disease invades and subdivides the target population into two classes: susceptibles (noninfectives) and infectives. Prior to the time of disease invasion, the population is assumed to be governed by a periodically forced demographic equation with a periodic recruitment function. Hence, the population is assumed to be either at a demographic "steady state" (an attracting cycle) or growing at a periodic