Intraspecific diversity in the fungal speciesChaunopycnis alba: Implications for microbial screening programs

Möller, C.; Weber, Gerhard; Dreyfuss, M.

doi:10.1007/bf01574767

Cited by 22 publications

(13 citation statements)

References 38 publications

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“…This is not uncommon, as infra-specific genetic differences have already been observed (Suay et al 2000). Indeed, distinct secondary metabolites can be produced by cospecific isolates in other fungi, as already reported in the literature (Möller et al 1996, Peláez et al 1998, Okino et al 2001. Thus, if secondary metabolic diversity is of interest, it is important to keep different samples/isolates of the same species of basidiomycetes in the collections.…”

Section: Resultsmentioning

confidence: 58%

Screening of Brazilian basidiomycetes for antimicrobial activity

Rosa

Machado

Jacob

et al. 2003

Mem. Inst. Oswaldo Cruz

100

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Section: Resultsmentioning

confidence: 58%

Screening of Brazilian basidiomycetes for antimicrobial activity

Rosa

Machado

Jacob

et al. 2003

Mem. Inst. Oswaldo Cruz

100

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“…Furthermore, they exhibit high homology among their ITS and 28S rDNA sequences. The cyclosporin peptide synthase gene cluster (MÖLLER, WEBER & DREYFUSS 1996), and a likely indole-diterpene gene cluster (see discussion) are operational in some strains. Their ability to be isolated from a variety of organic substrata indicates that they have high saprobic capacity.…”

Section: Figs 11-21mentioning

confidence: 98%

“…The extensive worldwide data of MÖLLER et al (MÖLLER, BUEHLER & DREYFUSS 1995, MÖLLER, WEBER & DREYFUSS 1996 demonstrated that the morphological species Chaunopycnis alba consisted of genetically, chemically, and ecologically distinct populations. Appropriate application of the phylogenetic species concept might resolve Chaunopycnis alba into more than one species (TAYLOR et al 2000).…”

Section: Figs 11-19mentioning

confidence: 98%

Chaunopycnis pustulata sp. nov., a new clavicipitalean anamorph producing metabolites that modulate potassium ion channels

et al. 2002

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“…The concept that microbial strains must be isolated from different geographical and climatic locations around the world in order to insure diversity in collections still gathers support (21,22).…”

Section: Introductionmentioning

confidence: 99%

Natural Products and Drug Discovery

Demain

Zhang

Natural Products

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SummaryFor more than 50 yr, natural products have served us well in combating infectious bacteria and fungi. During the 20th century, microbial and plant secondary metabolites helped to double our life span, reduced pain and suffering, and revolutionized medicine. The increased development of resistance to older antibacterial, antifungal, and antitumor drugs has been challenged by (1) newly discovered antibiotics (e.g., candins, epothilones); (2) new semisynthetic versions of old antibiotics (e.g., ketolides, glycylcyclines); (3) older underutilized antibiotics (e.g., teicoplainin); and (4) new derivatives of previously undeveloped narrow-spectrum antibiotics (e.g., streptogramins). In addition, many antibiotics are used commercially, or are potentially useful in medicine for purposes other than their antimicrobial action. They are used as antitumor agents, enzyme inhibitors including powerful hypocholesterolemic agents, immunosuppressive agents, antimigraine agents, and so on. A number of these products were first discovered as antibiotics that failed in their development as such, or as mycotoxins.It is unfortunate that the pharmaceutical industry has downgraded natural products just at the time that new assays are available and major improvements have been made in detection, characterization, and purification of small molecules. With the advent of combinatorial biosynthesis, thousands of new des4oeatives can now be made by a biological technique complementary to combinatorial chemistry. Furthermore, only a minor proportion of bacteria and fungi, i.e., 0.1-5%, have thus far been examined for secondary metabolite production. New methods are being developed to cultivate the so-called unculturable microbes from the soil and the sea. High-throughput screening (HTS) of combinatorial chemicals has not provided the numbers of high-quality leads that were anticipated. It has virtually eliminated the most unique source of chemical diversity, i.e., natural products, from the playing field, in favor of combinatorial chemistry. Combinatorial chemistry mainly yields minor modifications of present-day drugs and absolutely requires new scaffolds on which to build. Although comparative genomics is capable of disclosing new targets for drugs, the number of targets is so large that it requires tremendous investments of time and money to set up all the screens necessary to exploit this resource. This can be handled only by HTS methodology, which demands libraries of millions of chemical entities. Although such targets would be excellent for screening natural products, the industry has failed to exploit this unique opportunity and has opted to save funds by eliminating natural-product departments or decreasing their relevance in the hunt for new drugs. It is clear that the future success of the pharmaceutical industry depends on the combining of complementary technologies such as natural product discovery, HTS, integrative and systems biology, combinatorial biosynthesis, and combinatorial chemistry.

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Intraspecific diversity in the fungal speciesChaunopycnis alba: Implications for microbial screening programs

Cited by 22 publications

References 38 publications

Screening of Brazilian basidiomycetes for antimicrobial activity

Screening of Brazilian basidiomycetes for antimicrobial activity

Chaunopycnis pustulata sp. nov., a new clavicipitalean anamorph producing metabolites that modulate potassium ion channels

Natural Products and Drug Discovery

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