Intrastriatal transplantation of stem cells from human exfoliated deciduous teeth reduces motor defects in Parkinsonian rats

Zhang, Nan; Lu, Xianjie; Wu, Shichao; Li, Xueli; Duan, Jing; Chen, Chao; Wang, Wei; Song, Hao; Tong, Jiabei; Li, Sen; Liu, Yanming; Kang, Xinjiang; Wang, Xuexiang; Han, Fabin

doi:10.1016/j.jcyt.2018.02.371

Cited by 34 publications

(44 citation statements)

References 52 publications

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“…Zhang et al transplanted neural-primed SHED to the striatum of 6hydroxydopamine (6-OHDA)-induced rats with PD. 24 They found significant improvement in the recovery of the motor deficits. After transplantation, SHED was differentiated into dopamine neurons and integrated into the rat brain by forming synaptic connections.…”

Section: Parkinson's Disease (Pd)mentioning

confidence: 95%

Therapeutic applications of stem cells from human exfoliated deciduous teeth: a review

Baweja¹

2020

Int J Res Med Sci

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Dental stem cells have been found to have the ability to differentiate into nerve cells, adipose cells, chondrocytes, osteoblasts, myocytes, hepatocytes, and odontoblasts. They can be derived from permanent teeth or deciduous teeth. Stem cells from human exfoliated deciduous teeth (SHED) have a higher proliferation rate and higher osteogenic and neurogenic potential than dental pulp stem cells (DPSC). Therefore, SHEDs are an attractive cell source for tissue regeneration. A large plethora of in vitro and animal studies have been conducted in the last few decades that has demonstrated the potential uses of these cells for the treatment of oral and non-oral diseases. The aim of this article was to review the potential therapeutic applications of stem cells derived from human exfoliated deciduous teeth. A Medline search was done, including international literature, published in English between 2003 and 2020. In this area, further research is needed to ensure the applicability of SHED in the treatment of diseases in humans.

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Section: Parkinson's Disease (Pd)mentioning

confidence: 95%

Therapeutic applications of stem cells from human exfoliated deciduous teeth: a review

Baweja¹

2020

Int J Res Med Sci

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“…This indicates the potential of implanted SHED or its derivatives in the treatment of SCI in rodents and other neurodegenerative diseases. In addition, a large number of studies on the culture of SHED-derived neurospheres and the induction of dopaminergic neurons as well as the treatment of PD rat models have shown that they constitute a very suitable cell source for cell therapy in PD [22][23][24].…”

Section: Characteristics Of Shedmentioning

confidence: 99%

The potential therapy with dental tissue-derived mesenchymal stem cells in Parkinson’s disease

et al. 2021

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Parkinson’s disease (PD), the second most common neurodegenerative disease worldwide, is caused by the loss of dopaminergic (DAergic) neurons in the substantia nigra resulting in a series of motor or non-motor disorders. Current treatment methods are unable to stop the progression of PD and may bring certain side effects. Cell replacement therapy has brought new hope for the treatment of PD. Recently, human dental tissue-derived mesenchymal stem cells have received extensive attention. Currently, dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous teeth (SHED) are considered to have strong potential for the treatment of these neurodegenerative diseases. These cells are considered to be ideal cell sources for the treatment of PD on account of their unique characteristics, such as neural crest origin, immune rejection, and lack of ethical issues. In this review, we briefly describe the research investigating cell therapy for PD and discuss the application and progress of DPSCs and SHED in the treatment of PD. This review offers significant and comprehensive guidance for further clinical research on PD.

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“…Moreover, obtaining SHED from the pulp of deciduous teeth is atraumatic; further, SHED are associated with minimal ethical concerns regarding their extraction and use [12]. SHED exhibit a higher proliferative activity and neural differentiation ability [13] and may be capable of differentiating into neurons, dopaminergic neurons, sensory neurons, and retinal photoreceptor-like cells in vivo [14][15][16]. A recent study reported that SHED were capable of regenerating functional dental pulp with blood vessels and nerves in a large animal model.…”

Section: Introductionmentioning

confidence: 99%

Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats

Zhu

Min

Zeng

et al. 2020

Stem Cells International

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Stem cells from human exfoliated deciduous teeth (SHED) are a unique postnatal stem cell population with high self-renewal ability that originates from the cranial neural crest. Since SHED are homologous to the central nervous system, they possess superior capacity to differentiate into neural cells. However, whether and how SHED ameliorate degenerative central nervous disease are unclear. Chronic cerebral ischemia (CCI) is a kind of neurological disease caused by long-term cerebral circulation insufficiency and is characterized by progressive cognitive and behavioral deterioration. In this study, we showed that either systemic transplantation of SHED or SHED infusion into the hippocampus ameliorated cognitive impairment of CCI rats in four weeks after SHED treatment by rescuing the number of neurons in the hippocampus area. Mechanistically, SHED transplantation decreased the apoptosis of neuronal cells in the hippocampus area of CCI rats through downregulation of cleaved caspase-3. In summary, SHED transplantation protected the neuronal function and reduced neuronal apoptosis, resulting in amelioration of cognitive impairment from CCI. Our findings suggest that SHED are a promising stem cell source for cell therapy of neurological diseases in the clinic.

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Intrastriatal transplantation of stem cells from human exfoliated deciduous teeth reduces motor defects in Parkinsonian rats

Cited by 34 publications

References 52 publications

Therapeutic applications of stem cells from human exfoliated deciduous teeth: a review

Therapeutic applications of stem cells from human exfoliated deciduous teeth: a review

The potential therapy with dental tissue-derived mesenchymal stem cells in Parkinson’s disease

Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats

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