Intratesticular injection of a zinc-based solution for contraception of domestic cats: A randomized clinical trial of efficacy and safety

Oliveira, Edmundo Clarindo; Fagundes, Ana Katharyne F.; Melo, C. C. S. de; Nery, Lorena T.B.; Revorêdo, Renata Gomes; Andrade, Talita Franco; Oliveira-Esquerre, Karla Patrícia; Kastelic, John P.; Junior, V.A. Silva

doi:10.1016/j.tvjl.2013.01.011

Cited by 33 publications

(49 citation statements)

References 12 publications

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“…Although plasma testosterone concentrations were not significantly different from untreated controls, apparent effects on behaviour (e.g. reduced urine marking, vocalizing, fighting with other cats) were observed (Oliveira et al 2013). In contrast, a single injection of 20% calcium chloride resulted in significant dose-dependent degenerative changes of the testicular tissue.…”

Section: Sclerosing Agentsmentioning

confidence: 67%

“…reduced urine marking, vocalizing, fighting with other cats) were observed (Oliveira et al. ). In contrast, a single injection of 20% calcium chloride resulted in significant dose‐dependent degenerative changes of the testicular tissue.…”

Section: Sclerosing Agentsmentioning

confidence: 93%

“…Furthermore, testicular size was significantly decreased, and penile spines were either decreased (55% on day 120) or absent (36% on day 120) (Oliveira et al. ). Although plasma testosterone concentrations were not significantly different from untreated controls, apparent effects on behaviour (e.g.…”

Section: Sclerosing Agentsmentioning

confidence: 99%

“…Following an intratesticular injection of zinc gluconate, spermatogenesis was suppressed (azoospermia) in 91% (10/11) of toms on day 60 (the remaining cat had a reduced total sperm count and motility) and in 73% (8/11) on day 120 with the other two toms showing necrospermia or poor semen quality (Oliveira et al 2013). Furthermore, testicular size was significantly decreased, and penile spines were either decreased (55% on day 120) or absent (36% on day 120) (Oliveira et al 2013). Although plasma testosterone concentrations were not significantly different from untreated controls, apparent effects on behaviour (e.g.…”

Section: Sclerosing Agentsmentioning

confidence: 99%

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Suppression of Fertility in Adult Cats

Goericke-Pesch

Wehrend

Georgiev

2014

Reprod Domestic Animals

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Contents Cats are animals with highly efficient reproduction, clearly pointing to a need for suppression of fertility. Although surgical contraception is highly effective, it is not always the method of choice. This is predominantly because it is cost‐intensive, time‐consuming and irreversible, with the latter being of major importance for cat breeders. This article reviews the use of progestins, scleroting agents, immunocontraception, melatonin, GnRH antagonists and finally, GnRH agonists, in adult male and female cats in detail, according to the present state of the art. By now, various scientific and clinical options are available for the suppression of fertility in adult cats and the decision as to which should be chosen – independent of the legal registration of any state – depends on different facts: (i) feral or privately owned animal? (ii) temporary or permanent suppression of fertility wanted/needed? (iii) sex of the animal? New effective and available methods for hormonal contraception include melatonin implants for short‐term post ponement of oestrus in adult queens and slow‐release GnRH‐agonist implants containing deslorelin (Suprelorin®) for short‐ and long‐term contraception in male and female companion and breeding cats.

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Section: Sclerosing Agentsmentioning

confidence: 67%

Section: Sclerosing Agentsmentioning

confidence: 93%

Section: Sclerosing Agentsmentioning

confidence: 99%

Section: Sclerosing Agentsmentioning

confidence: 99%

See 2 more Smart Citations

Suppression of Fertility in Adult Cats

Goericke-Pesch

Wehrend

Georgiev

2014

Reprod Domestic Animals

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“…Propofol sedation was used to facilitate the injection and to avoid leakage, which could promote scrotal lesions (Oliveira et al, ). No scrotal damage was seen in most of the dogs treated with CaCl 2 ( n = 5), which is consistent with the results shown, after chemical castration, with zinc gluconate (Oliveira et al, ) and CaCl 2, in several species, including dogs (Canpolat, Gur, Gunay, Bulut, & Eroksuz, ; Kuladip Jana & Samanta, ; Mitra & Samanta, ; Paranzini, Cardoso, Souza, Vieira, & Martins, ; Paranzini et al, ; Pereira, ).…”

Section: Discussionmentioning

confidence: 99%

Calcium chloride combined with dimethyl sulphoxide for the chemical sterilization of dogs

Silva

Paranzini

Franco

et al. 2018

Reprod Domestic Animals

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The aim of this study was to evaluate the effect of intratesticular injection of calcium chloride (CaCl ) combined with dimethyl sulphoxide (DMSO) as a chemical sterilization in dogs. Twelve dogs were divided into two groups: the treated group (n = 6), in which 15 mg/kg of a 7.5% CaCl solution combined with 0.5% DMSO was injected into each testicle (volume range 1.0-4.76 ml); and a control group (n = 6) that received the same volume/kg of 0.9% sodium chloride solution (NaCl). Semen characteristics pre- and post-treatment were evaluated. Serum testosterone concentration was determined before the injection (D-1) and at 15 (D15), 30 (D30) and 60 (D60) days after intratesticular injection. Testicle sizes and local pain were evaluated for 7 consecutive days (D1 to D7) and at D15, D30 and D60 after injection. At D60, testicle histological evaluation was performed after orchiectomy. No pain was observed by testicular palpation, with the exception of one dog in the treated group; this dog then received analgesic therapy. An increase in testicular volume was evident within 24 hr after treatment, followed by gradual reduction for 3 weeks. Five of 6 dogs from the treated group presented azoospermia at D15; the remaining dog presented at D30. There was no significant difference in testosterone concentrations in the treated group during the experimental period. Histological evaluation showed testicular degenerative lesions, especially at the proximal and middle portions. The results indicated that one injection of 7.5% CaCl combined with 0.5% DMSO into each testis is a viable alternative for canine sterilization.

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