Intrathecal Administration

Kilburn, Lindsay; Berg, Stacey L.; Blaney, Susan M.

doi:10.1007/978-1-4614-9135-4_23

Cancer Drug Discovery and Development

2013

DOI: 10.1007/978-1-4614-9135-4_23

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Intrathecal Administration

Lindsay Kilburn¹,

Stacey L. Berg²,

Susan M. Blaney³

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2015

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Cited by 1 publication

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Cerebrospinal Fluid (CSF) Directed Antineoplastic Agents: A Review of Current Knowledge

Mol¹,

er²,

Caraway³

et al. 2015

JCPCR

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Barriers to Drug Transport There are three proposed barrier systems to drug transport in the brain: the blood-CSF barrier, the blood-brain barrier (BBB), and the CSF-brain barrier [2]. The first barrier refers to the epithelial cells of the choroid plexus that resides within the CSF of the lateral, third, and fourth ventricles [2,5,6]. This barrier regulates drug transfer from the blood to the CSF [6]. The second barrier refers to the capillary endothelial cells of the brain. This barrier regulates drug transfer from the blood to the interstitial fluid (ISF) that bathes the CNS parenchyma [2,6].

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Cerebrospinal Fluid (CSF) Directed Antineoplastic Agents: A Review of Current Knowledge

Mol¹,

er²,

Caraway³

et al. 2015

JCPCR

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Intrathecal Administration

Cited by 1 publication

References 83 publications

Cerebrospinal Fluid (CSF) Directed Antineoplastic Agents: A Review of Current Knowledge

Cerebrospinal Fluid (CSF) Directed Antineoplastic Agents: A Review of Current Knowledge

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