Intrathecal Delivery of Ketorolac Loaded &lt;i&gt;In Situ&lt;/i&gt; Gels for Prolonged Analgesic and Anti-Inflammatory Activity in Vertebral Fracture

Cao, Shu-e; Chen, Shengyang; Tian, Jianmin; Zhang, Xiaoran; Li, Jun; Gong, Hong-Yan; Xiu-qin, Yue

doi:10.4314/tjpr.v15i1.1

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…It was also found that higher the gelatin concentration used for formulation of implants higher is the drug content. The results were well supported with previous studies [12][13][14][15].…”

Section: Discussionsupporting

confidence: 93%

Polymeric implants of diclofenac for site specific and prolonged drug delivery for use in orthopedic or arthritic patients.

Mishra¹

2016

Adv. Biomed. Pharma.

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In the present study, diclofenac loaded implants were prepared for prolonged and site specific drug delivery in orthopedics and other related areas. The polymeric biodegradable implants of diclofenac were prepared using sodium alginate and gelatin by solvent evaporation method. The prepared implants were characterized for various physico-chemical parameters (like visual appearance, thickness, weight variation, drug content, formaldehyde test) and in-vitro drug release (in franz diffusion cell). The surfaces of prepared implants were smooth and shiny with yellow colour. Drug content was found to be 98.56 ± 1.98 and 97.99 ± 1.60 % for formulation F1 and F2, respectively. Both formulations of implant were free from free formaldehyde. In the in vitro drug release study the drug release across the membrane was 95.11 ± 2.26 and 91.66 ± 2.08 % at the end of 24 h. The implants prepared with gelatin and sodium alginate in 3:1 ratio was concluded to be the better formulation. The study concluded that the biodegradable implants of diclofenac might be effective in orthopedics for getting prolonged drug release.

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Section: Discussionsupporting

confidence: 93%

Polymeric implants of diclofenac for site specific and prolonged drug delivery for use in orthopedic or arthritic patients.

Mishra¹

2016

Adv. Biomed. Pharma.

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“…The most important aspects of the in situ gels system are that these gels can be delivered in a non-invasive manner using diverse route for administrations. Intrathecal [38], buccal, intraperitoneal (i.p. ), vaginal [39], ocular [40, 41], nasal [42] and rectal routes of administrations for in situ gels are being exploited for various drugs.…”

Section: In Situ Forming Gels: Synthesis Polymers Routes Of Deliverymentioning

confidence: 99%

Bioresponsive Injectable Hydrogels for On-demand Drug Release and Tissue Engineering

Vashist

Alexis

Jayant

et al. 2017

CPD

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The emergence of injectable hydrogels as biomaterials has been a revolutionary breakthrough in the field of on-demand drug delivery and tissue engineering. The promising features of these systems include their biodegradability, biocompatibility, permeability, ease of the surgical implantation, and most importantly exhibit minimally invasiveness. These hydrogels have been explored as sustained and on-demand release carriers for the various bioactive agents, growth factors, live cells, various hydrophobic drugs and as extracellular matrices for tissue engineering. Present review is an attempt to highlight the recent systems explored for on-demand drug release and tissue engineering. It also gives an overview of the role of nanotechnology in the advancements of injectable hydrogels. The future prospects and challenges of these hydrogels have also been addressed.

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Acute spinal cord injury: A review of pathophysiology and potential of non-steroidal anti-inflammatory drugs for pharmacological intervention

Hayta

Elden

2018

Journal of Chemical Neuroanatomy

103

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Intrathecal Delivery of Ketorolac Loaded <i>In Situ</i> Gels for Prolonged Analgesic and Anti-Inflammatory Activity in Vertebral Fracture

Cited by 3 publications

References 18 publications

Polymeric implants of diclofenac for site specific and prolonged drug delivery for use in orthopedic or arthritic patients.

Polymeric implants of diclofenac for site specific and prolonged drug delivery for use in orthopedic or arthritic patients.

Bioresponsive Injectable Hydrogels for On-demand Drug Release and Tissue Engineering

Acute spinal cord injury: A review of pathophysiology and potential of non-steroidal anti-inflammatory drugs for pharmacological intervention

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