Intrathecal injection of an oxytocin-receptor antagonist attenuated postnephrectomy natriuresis in the male rat

Huang, Wan; Zhai, Qing; Sjöquist, Mats

doi:10.1016/0304-3940(95)11773-p

Cited by 4 publications

(2 citation statements)

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“…Afferent renal and brain pathways may also be altered in the knockout mice. OT antagonists attenuated the natriuresis following unilateral nephrectomy (19) and hypotensioninduced renin, vasopressin, and HR responses (18). These results suggest that OT (besides its direct peripheral effects) is involved in the afferent signaling of the acute renal responses.…”

Section: Discussionmentioning

confidence: 72%

“…Changes in tachycardic response were not observed in rats following OT receptor blockade restricted to the NTS/DCV (16), indicating a more generalized action of OT in the central adjustment of HR. The full anatomic map for central oxytocinergic control of cardiovascular function is not established; however, pieces of the puzzle indicate participation of the hypothalamic paraventricular nucleus (site of peptide biosynthesis) (8,29), NTS/DVC brain stem integrative centers (5,11,16,36), and the spinal cord (19,41,43).…”

Section: Discussionmentioning

confidence: 99%

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Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice

Michelini

Marcelo

Amico

et al. 2003

American Journal of Physiology-Heart and Circulatory Physiology

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Oxytocin (OT) has been implicated in the cardiovascular responses to exercise, stress, and baroreflex adjustments. Studies were conducted to determine the effect of genetic manipulation of the OT gene on blood pressure (BP), heart rate (HR), and autonomic/baroreflex function. OT knockout (OTKO -/-) and control +/+ mice were prepared with chronic arterial catheters. OTKO -/- mice exhibited a mild hypotension (102 +/- 3 vs. 110 +/- 3 mmHg). Sympathetic and vagal tone were tested using beta(1)-adrenergic and cholinergic blockade (atenolol and atropine). Magnitude of sympathetic and vagal tone to the heart and periphery was not significantly different between groups. However, there was an upward shift of sympathetic tone to higher HR values in OTKO -/- mice. This displacement combined with unchanged basal HR led to larger responses to cholinergic blockade (+77 +/- 25 vs. +5 +/- 15 beats/min, OTKO -/- vs. control +/+ group). There was also an increase in baroreflex gain (-13.1 +/- 2.5 vs. -4.1 +/- 1.2 beats x min(-1) x mmHg(-1), OTKO -/- vs. control +/+ group) over a smaller BP range. Results show that OTKO -/- mice are characterized by 1) hypotension, suggesting that OT is involved in tonic BP maintenance; 2) enhanced baroreflex gain over a small BP range, suggesting that OT extends the functional range of arterial baroreceptor reflex; and 3) shift in autonomic balance, indicating that OT reduces the sympathetic reserve.

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Section: Discussionmentioning

confidence: 72%