Intrathoracic multicentric Castleman disease: CT findings in 12 patients.

Johkoh, Takeshi; Müller, N L; Ichikado, Kazuya; Nishimoto, Norihiro; Yoshizaki, Kazuyuki; Honda, Osamu; Tomiyama, Noriyuki; Naitoh, H; Nakamura, Hidenori; Yamamoto, Shinya

doi:10.1148/radiology.209.2.9807577

Cited by 123 publications

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“…No radiological data were available [4]. Interstitial pneumonitis has been reported as a pulmonary feature of MCD in 12 patients [17]. However, no clinical data or HIV serological status were available in this study.…”

Section: Discussionmentioning

confidence: 89%

Pulmonary manifestations of multicentric Castleman's disease in HIV infection: a clinical, biological and radiological study

Guihot

Lj²,

Agbalika³

et al. 2005

Eur Respir J

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The aim of the present study was to report clinical, radiological and bronchoalveolar lavage (BAL) findings in patients with pulmonary manifestations of HIV-associated multicentric Castleman's disease (MCD).This was a retrospective study of 12 patients with histologically proven MCD. Clinical manifestations were as follows: dyspnoea (nine out of 12 cases), cough (n510), bilateral crackles (n510), together with high fever, malaise, peripheral lymphadenopathy (n512), and hepatosplenomegaly (n510). Two patients developed acute respiratory distress syndrome. Chest radiographs and computed tomography scans showed reticular (n57) and/or nodular (n57) interstitial patterns, with mediastinal lymphadenopathy (n59), and bilateral pleural effusion (n53). Fibreoptic endoscopy was normal in all cases. BAL analysis showed hypercellularity (n56) and/or lymphocytosis (n56), and human herpesvirus-8 DNA was detected in two out of two cases. Specific stains and cultures for pathogens were negative. All patients received etoposide and/or vinblastine, and improved after 2-4 days. Relapses were frequent (50 attacks in 12 patients). Six patients developed a non-Hodgkin's lymphoma, and five died.In conclusion, the pulmonary manifestation of HIV-related multicentric Castleman's disease is an acute reticulo-nodular interstitial pneumonitis, associated with severe systemic symptoms and peripheral lymphadenopathy. In bronchoalveolar lavage fluid, cellularity is not specific and human herpesvirus-8 DNA is detected. The clinical course is specific due to a rapid onset and regression, frequent relapses and a high occurrence of non-Hodgkin's lymphoma.

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Section: Discussionmentioning

confidence: 89%

Pulmonary manifestations of multicentric Castleman's disease in HIV infection: a clinical, biological and radiological study

Guihot

Lj²,

Agbalika³

et al. 2005

Eur Respir J

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“…It was reported that calcification might be observed in 5%-10% of patients. On the other hand, multicentric lesions can typically be observed in the form of bilateral hilar and mediastinal lymphadenopathy, centrilobular nodular opacity, and rarely ground glass, consolidation, and bronchiectasis (10,12). The value of PET in diagnosis is disputed, as it is not able to distinguish between malignant disease and CD.…”

Section: Discussionmentioning

confidence: 99%

Intrathoracic Castleman disease

Biçakçioğlu¹,

Gülhan²,

Acar³

et al. 2014

Turk J Med Sci

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Isolation and identification of Avibacterium paragallinarum, the causative agent of infectious coryza, is considered a challenging task in laboratories with limited specialties. In the present study, 14 commercial layer fowls showing the typical symptoms of infectious coryza were subjected to primary isolation followed by polymerase chain reaction confirmation of suspect colonies (culture-PCR). Direct PCR assays on infraorbital sinus swab samples were also carried out. Thirty-five suspected cases of infectious coryza in commercial broiler chickens were also screened using direct PCR on infraorbital sinus swabs. In culture-PCR, only 1 of the 4 suspected isolates was confirmed as Av. paragallinarum. In comparison, in direct PCR, 5 layer samples were shown to be positive for Av. paragallinarum. All of the broiler samples were negative in the direct PCR assay. Our findings indicate that primary isolation in combination with PCR can be a simple method for diagnosis of infectious coryza, although with a lower sensitivity than direct PCR. While direct PCR is comparably the more rapid and sensitive test, there will be instances in which the bacterial isolate is needed for further use. Hence, the culture-PCR method can be a practical and simple approach, especially in laboratories with limited specialty in identification of this fastidious organism.

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“…Hilar, mediastinal, and axillary lymphadenopathy are common, and lymphadenopathy may enhance with intravenous injection of contrast material (Fig 10) (45). Ground-glass opacities, consolidation, and bronchiectasis are less common CT findings (45). Hepatosplenomegaly, ascites, diffuse lymphadenopathy, and thickening of the retroperitoneal fascia may also occur (46).…”

Section: Multicentric Castleman Diseasementioning

confidence: 99%

Thoracic Diseases Associated with HIV Infection in the Era of Antiretroviral Therapy: Clinical and Imaging Findings

Chou¹,

Prabhu²,

Crothers³

et al. 2014

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Abbreviations: AIDS = acquired immunodeficiency syndrome, ART = antiretroviral therapy, COPD = chronic obstructive pulmonary disease, EBV = Epstein-Barr virus, HHV-8 = human herpesvirus 8, HIV = human immunodeficiency virus, IRIS = immune reconstitution inflammatory syndrome, KICS = KSHV inflammatory cytokine syndrome, KSHV = Kaposi sarcomaassociated herpesvirus, LIP = lymphocytic interstitial pneumonia, MAC = Mycobacterium avium complex, MCD = multicentric Castleman disease, MTC = multilocular thymic cyst, PAH = pulmonary arterial hypertension

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Intrathoracic multicentric Castleman disease: CT findings in 12 patients.

Abstract: Multicentric Castleman disease is characterized by the presence of systemic symptoms, bilateral hilar and mediastinal lymphadenopathy, and centrilobular nodular opacities. The pulmonary parenchymal findings are due to the associated lymphocytic interstitial pneumonitis.

Cited by 123 publications

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Pulmonary manifestations of multicentric Castleman's disease in HIV infection: a clinical, biological and radiological study

Pulmonary manifestations of multicentric Castleman's disease in HIV infection: a clinical, biological and radiological study

Intrathoracic Castleman disease

Thoracic Diseases Associated with HIV Infection in the Era of Antiretroviral Therapy: Clinical and Imaging Findings

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