Intratracheal exposure of the guinea pig lung to cadmium and/or selenium: a histological evaluation

Bell, Robert J.; Nonavinakere, Vani K.; Soliman, Magdi R.I.

doi:10.1016/s0378-4274(99)00286-6

Cited by 34 publications

(16 citation statements)

References 12 publications

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“…For example, the earliest stages of Cd-induced lung injury primarily involve the disruption of the alveolar septum and the leakage of fluid and solutes into the alveoli (Bus et al, 1978;Pearson and Prozialeck, 2001). However, these early stages of injury are soon followed by the influx and activation of leukocytes and the release of inflammatory mediators that facilitate the inflammatory processes responsible for subsequent pulmonary injury and fibrosis (Bell et al, 2000;Driscoll et al, 1992;Frankel et al, 1991;Hirano et al, 1989).…”

Section: Pulmonary Injurymentioning

confidence: 99%

The vascular endothelium as a target of cadmium toxicity

2006

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Section: Pulmonary Injurymentioning

confidence: 99%

The vascular endothelium as a target of cadmium toxicity

2006

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“…In the literatures, there have been several reports of cadmium-induced apoptosis in vitro studies (6)(7)(8), and in vivo studies of kidney (9), testis (10) and liver (11). But only a few studies related with apoptosis in the cadmium-induced acute lung injury in vivo were reported (4,12).…”

Section: Introductionmentioning

confidence: 99%

Cadmium Induced Acute Lung Injury and TUNEL Expression of Apoptosis in Respiratory Cells

et al. 2003

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We examined the ultrastructural features of the lung parenchyma and the expression of apoptosis of the respiratory cells by TUNEL technique. Male Sprague-Dawley rats (n=30) were intra-tracheally injected with cadmium (2.5 mg/kg) into both lungs. The light and electron microscopic features of the lung tissues were examined on Days 1, 3, 7 and 10 after the injection of cadmium. Specimen preparations for the light and electron microscopic TUNEL stains were performed. Ultrastructurally, on Days 1 and 3, the alveolar spaces were filled with edematous fluid, and desquamated type I epithelial cells. On Days 7 and 10, the alveolar spaces and interstitium were patchy infiltrated with young fibroblasts and some collagen deposition. The light microscopic TUNEL stain showed that apoptosis of the alveolar cells was most prominent on Day 1, and then the number of apoptosis was markedly decreased on Days 3, 7 and 10. The electron microscopic TUNEL stain showed the electron dense homogenous nuclear expression, and the formation of intranuclear blebs which protrude to the outside of nuclei. On Days 7 and 10, there are frequent apoptotic nuclear bodies in the alveolar macrophages. We could examine the identification of the equivocal apoptotic cells and various morphologic expression of apoptotic nuclei on the electron microscopic TUNEL stain.

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“…Long-term exposure to low concentrations of cadmium results in upregulation of proinflammatory cytokines and cell cycle regulatory molecules, leading to chronic infections [14], inflammation and cell proliferation [15]. In case one, cadmium poisoning was combined with pneumonia.…”

Section: Analysis and Discussionmentioning

confidence: 99%

“…Cadmium-induced lung damage and inflammation have been reported [14,15]. Long-term exposure to low concentrations of cadmium results in upregulation of proinflammatory cytokines and cell cycle regulatory molecules, leading to chronic infections [14], inflammation and cell proliferation [15].…”

Section: Analysis and Discussionmentioning

confidence: 99%