Intratracheal perfluorocarbon administration combined with mechanical ventilation in experimental respiratory distress syndrome

As, Tütüncü; Ns, Faithfull; Lachmann, Burkhard

doi:10.1097/00003246-199307000-00008

Cited by 186 publications

(51 citation statements)

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“…The increased survival was attributed to a preserved oxygen delivery with PLV, which deteriorated in the non-PFC-treated control group. The authors also partially confirm previous experiences with PLV in animal models of acute lung injury (ALI), which have shown that: 1) Higher doses of PFC lead to higher levels of oxygenation [7]. This is suggested to result from dose-dependent recruitment of collapsed atelectatic alveoli by PFC fluid.…”

supporting

confidence: 84%

Partial liquid ventilation

Verbrugge¹,

Lachmann²

1997

Eur Respir J

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supporting

confidence: 84%

Partial liquid ventilation

Verbrugge¹,

Lachmann²

1997

Eur Respir J

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“…It has been shown that in surfactant-deficient animal lungs PLV provides adequate gas exchange as long as a sufficient amount of PFC is present in the lungs [10 -13]. The present group has demonstrated that higher doses of PFC lead to higher levels of oxygenation in animals suffering from acute respiratory failure as a result of dose-dependent recruitment of collapsed atelectatic alveoli by PFC [10,11]. It is also known that oxygenation deteriorates over time if no additional doses of PFC are instilled; this is attributed to evaporation of PFC which will cause affected alveoli to collapse [10,11].…”

Section: Discussionmentioning

confidence: 67%

“…The PFC used in this study (Liquivent1, Alliance Pharmaceutical, San Diego, CA, USA) is insoluble in water, has a specific gravity of 1.918 g?cm -1 at 25uC, a surface tension of 18.1 dynes?cm -1 , vapour pressure of 3.6 torr (0.5 kPa) at 20uC and 10.5 torr (1.4 kPa) at 37uC, an oxygen solubility of 53 mL?100 mL -1 and CO 2 solubility of 210 mL?100 mL -1 at 37uC, at 1 atmosphere pressure [10,11]. The groups PFC10 and PFC20 received a single dose of PFC intratracheally.…”

Section: Treatment With Perfluorocarbonsmentioning

confidence: 99%

“…Based on this low surface tension, the resulting peak inspiratory pressure (PIP) during volume-controlled ventilation are reduced [10,11,13]. Another property of PFCs is their high density which, mainly in the dependent part of the lung, recruits collapsed alveolar units [14,15]; the combination of PFCs with gas ventilation, better known as partial liquid ventilation (PLV), also improves gas exchange in surfactant-deficient lungs [10,11]. Additionally, because PFCs might not be affected by the presence of plasma proteins in the alveolus, PFC might prove useful as a treatment for ventilation-induced injury [16,17].…”

mentioning

confidence: 99%

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Partial liquid ventilation improves lung function in ventilation-induced lung injury

Anda

Lachmann²,

Verbrugge³

et al. 2001

Eur Respir J

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Disturbances in lung function and lung mechanics are present after ventilation with high peak inspiratory pressures (PIP) and low levels of positive endexpiratory pressure (PEEP). Therefore, the authors investigated whether partial liquid ventilation can re-establish lung function after ventilation-induced lung injury.Adult rats were exposed to high PIP without PEEP for 20 min. Thereafter, the animals were randomly divided into five groups. The first group was killed immediately after randomization and used as an untreated control. The second group received only sham treatment and ventilation, and three groups received treatment with perfluorocarbon (10 mL?kg -1 , 20 mL?kg -1 , and 20 ml?kg -1 plus an additional 5 mL?kg -1 after 1 h). The four groups were maintained on mechanical ventilation for a further 2-h observation period. Blood gases, lung mechanics, total protein concentration, minimal surface tension, and small/large surfactant aggregates ratio were determined.The results show that in ventilation-induced lung injury, partial liquid ventilation with different amounts of perflubron improves gas exchange and pulmonary function, when compared to a group of animals treated with standard respiratory care. These effects have been observed despite the presence of a high intra-alveolar protein concentration, especially in those groups treated with 10 and 20 mL of perflubron.The data suggest that replacement of perfluorocarbon, lost over time, is crucial to maintain the constant effects of partial liquid ventilation. Eur Respir J 2001; 18: 93-99.

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“…On the other hand, a shorter PFD aerosolization time was needed to improve lung mechanics; C dyn significantly had already improved in the PFC aerosol group by 30 min after the initiation of the therapy. On the basis of our bench studies (14,21), at 30 min of therapy, a PFD dose of ~3-3.5 ml/kg would have effectively reached the lung, which corresponds to the minimal dose of PFC to significantly improve C dyn according to Tütüncu et al (9).…”

Section: Discussionmentioning

confidence: 79%

Aerosolized perfluorocarbon improves gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndrome

et al. 2012

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Background: aerosolized perfluorocarbon (PFc) has been proposed as an alternative method of PFc administration; however, the efficacy of aerosolized PFc in a preterm animal model has not yet been demonstrated. Methods: Twelve preterm lambs were randomized to two groups: a perfluorodecalin (PFD) aerosol group (n = 6) receiving 10 ml/kg/h of PFD delivered by an intratracheal inhalation catheter followed by 4 h of mechanical ventilation (MV) or the control group, in which animals (n = 6) were managed for 6 h with MV. Gas exchange, pulmonary mechanics, cardiovascular parameters, and cerebral blood flow (cBF) were measured. results: Both groups developed hypoxia, hypercarbia, and acidosis at baseline. aerosolized PFD improved oxygenation (P < 0.0001) and pulmonary mechanics (P < 0.0001) and changed carbon dioxide values to normal physiological levels, unlike the treatment given to the controls (P < 0.0003). The time course of mean arterial blood pressure and cBF were significantly affected by PFD aerosolization, especially during the first hour of life. cBF gradually decreased during the first hour in the PFD aerosol group and remained stable until the end of the follow-up, whereas cBF remained higher in the control group (P < 0.0028). conclusion: aerosolized PFD improves pulmonary function in preterm lambs and should be further investigated as an alternative mode of PFc administration.

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Intratracheal perfluorocarbon administration combined with mechanical ventilation in experimental respiratory distress syndrome

Cited by 186 publications

References 0 publications

Partial liquid ventilation

Partial liquid ventilation

Partial liquid ventilation improves lung function in ventilation-induced lung injury

Aerosolized perfluorocarbon improves gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndrome

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