Intratumor cisplatin nephrotoxicity in combined laser‐induced thermal therapy for cancer treatment

Palumbo, Marcel N.; Cervantes, Onivaldo; Eugenio, Cecilia; Hortense, Flávia Tatiana Pedrolo; Ribeiro, João Carlos; Paolini, A; Tedesco, Antônio Cláudio; Sercarz, Joel A.; Paiva, Marcos B.

doi:10.1002/lsm.22685

Cited by 7 publications

(13 citation statements)

References 44 publications

(74 reference statements)

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“…34,35 Chemophototherapy has emerged as a promising treatment option for solid tumors. 18 Some studies have shown that a combination of DOX-based chemotherapy and ICG-based phototherapy can enhance antitumor efficacy and minimize systemic toxicity. [40][41][42][43] DOX is a broad-spectrum antitumor antibiotic that can inhibit the synthesis of RNA and DNA.…”

Section: Discussionmentioning

confidence: 99%

“…5 The combination of chemotherapy and phototherapy has emerged as a promising strategy for cancer therapy, preclinically and clinically. 5,18 Concurrent introduction of chemotherapeutics can enhance the efficacy of phototherapy by further damaging tumor cells, preventing regrowth. Additionally, anticancer drugs themselves may generate oxidative stress, producing hydroxyl radicals which, when combined with PDT, may be sufficient to induce cell cycle arrest and subsequent cytotoxic death of cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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The synthesis and application of nano doxorubicin-indocyanine green matrix metalloproteinase-responsive hydrogel in chemophototherapy for head and neck squamous cell carcinoma

Wang

et al. 2019

IJN

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BackgroundHead and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies, with high rates of mortality and morbidity worldwide. Owing to the special anatomical location of this tumor, an effective, minimally invasive treatment with low systemic toxicity is highly desirable. Hydrogels have shown great potential for tumor-targeting therapy, with excellent performance. However, there have been few reports on co-loading photosensitizers and chemotherapeutic drugs into hydrogels. In this study, we synthesized a nano doxorubicin-indocyanine green matrix metalloproteinase (MMP)-responsive hydrogel (denoted as NDIMH), combining chemotherapy and phototherapy, to achieve superior antitumor efficacy.MethodsFirst, NDIMH was synthesized and characterized by scanning electron microscopy and drug-release assays. Second, the photosensitivity properties and antitumor efficiency of this drug delivery system were studied in vivo and in vitro. Last, the imaging and biodistribution of NDIMH were monitored using the Maestro EX in vivo imaging system.ResultsThe nanodrugs loaded into the smart hydrogel exhibited uniform size distribution, excellent size stability, and a sustained release in the presence of MMP-2. NDIMH showed ideal photosensitivity characteristics under light. NDIMH with 808 nm near-infrared (NIR) irradiation effectively inhibited the viability, invasion, and metastasis of SCC-15 in vitro. After intratumoral injection of NDIMH with 808 nm NIR illumination, the hydrogels exhibited favorable synergistic antitumor efficacy and acceptable biosafety. Additionally, fluorescence imaging showed that NDIMH could significantly improve the retention of nanodrugs at the tumor site.ConclusionThe intratumoral injection of NDIMH with 808 nm NIR irradiation could be a promising chemophototherapy alternative for HNSCC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The synthesis and application of nano doxorubicin-indocyanine green matrix metalloproteinase-responsive hydrogel in chemophototherapy for head and neck squamous cell carcinoma

Wang

et al. 2019

IJN

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“…Cisplatin is one of most commonly used chemotherapeutic drugs in the treatment of solid tumors including liver [1], lung [2], breast [3], cervical [4], ovarian [5], and testis [6] cancers. Although cisplatin has been shown to be one of the most effective anticancer drugs, its use in clinical application is limited because of its side effects in normal tissues [7–9]. The major consequences during cisplatin treatment are nephrotoxicity, ototoxicity, and neurotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Sirt5 Attenuates Cisplatin-Induced Acute Kidney Injury through Regulation of Nrf2/HO-1 and Bcl-2

Yang

et al. 2019

BioMed Research International

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Cisplatin- (CDDP) induced acute kidney injury (AKI) limits the clinical use of cisplatin. Several sirtuin (SIRT) family proteins are involved in AKI, while the roles of Sirt5 in cisplatin-induced AKI remain unknown. In the present study, we characterized the role and mechanism of Sirt5 in cisplatin-induced apoptosis using the human kidney 2 (HK-2) cell line. CDDP treatment decreased Sirt5 expression of HK-2 cells in a dose-dependent manner. In addition, Sirt5 overexpression enhanced the metabolic activity in CDDP-treated HK-2 cells while Sirt5 siRNA attenuated it. Forced expression of Sirt5 inhibited CDDP-induced apoptosis while Sirt5 siRNA showed the opposite effects. Accordingly, Sirt5 overexpression inhibited the level of caspase 3 cleavage and cytochrome c levels. Furthermore, we found that Sirt5 increased mitochondrial membrane potentials and ameliorated intracellular ROS production. Mitotracker Red staining indicated that Sirt5 overexpression was able to maintain the mitochondrial density during CDDP treatment. We also investigated possible downstream targets of Sirt5 and found that Sirt5 increased Nrf2, HO-1, and Bcl-2 while it decreased Bax protein expression. Sirt5 siRNA showed the opposite effect on these proteins. The levels of Nrf2, HO-1, and Bcl-2 proteins in HK-2 cells were also decreased after CDDP treatment. Moreover, Nrf2 and Bcl-2 siRNA partly abolished the protecting effect of Sirt5 on CDDP-induced apoptosis and cytochrome c release. Catalase inhibitor 3-AT also abolished the cytoprotective effect of Sirt5. Together, the results demonstrated that Sirt5 attenuated cisplatin-induced apoptosis and mitochondrial injury in human kidney HK-2 cells, possibly through the regulation of Nrf2/HO-1 and Bcl-2.

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“…This suggests that an alternative therapy should be considered for laryngeal SCC instead of additional PDT. Recently, some alternative or new therapies were reported that they showed noticeable differences in salvage treatment efficacy for head and neck cancers . They may be the alternative or salvage treatment before undertaking radical therapies.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic therapy in patients with head and neck squamous cell carcinoma

Hosokawa

Takebayashi²,

Takahashi³

et al. 2018

Lasers Surg Med

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Intratumor cisplatin nephrotoxicity in combined laser‐induced thermal therapy for cancer treatment

Cited by 7 publications

References 44 publications

The synthesis and application of nano doxorubicin-indocyanine green matrix metalloproteinase-responsive hydrogel in chemophototherapy for head and neck squamous cell carcinoma

The synthesis and application of nano doxorubicin-indocyanine green matrix metalloproteinase-responsive hydrogel in chemophototherapy for head and neck squamous cell carcinoma

Sirt5 Attenuates Cisplatin-Induced Acute Kidney Injury through Regulation of Nrf2/HO-1 and Bcl-2

Photodynamic therapy in patients with head and neck squamous cell carcinoma

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