Intratumoral multinucleated giant cells are not a prognostic pathologic feature in cutaneous melanoma

Srisuttiyakorn, Chutika; Bulloch, Kaleigh; Rodić, Nemanja; Bosenberg, Marcus W.; Ariyan, Stephen; Narayan, Deepak; Rothberg, Bonnie E. Gould; Galan, Anjela

doi:10.1111/cup.12750

Cited by 4 publications

(1 citation statement)

References 47 publications

(69 reference statements)

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“…The percentage of polyploidy reached a maximum of 7% of cells with 8N after 48 h incubation (Figure 4G), demonstrating that GlcSph induced the formation of multinucleated cells in a human melanoma cell line. Of note, giant multinucleated cells have been described in histopathologic analyses of melanoma [160,161], but their presence does not seem to be associated with poor prognosis [162]. Usually, aneuploidy confers pro-tumoral properties to cancer cells [163].…”

Section: Glcsph Promotes Necrosis and Produces Multinucleated Melanom...mentioning

confidence: 99%

Potential Role of Sphingolipidoses-Associated Lysosphingolipids in Cancer

Dubot

Astudillo

Therville

et al. 2022

Cancers

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Sphingolipids play a key structural role in cellular membranes and/or act as signaling molecules. Inherited defects of their catabolism lead to lysosomal storage diseases called sphingolipidoses. Although progress has been made toward a better understanding of their pathophysiology, several issues still remain unsolved. In particular, whether lysosphingolipids, the deacylated form of sphingolipids, both of which accumulate in these diseases, are simple biomarkers or play an instrumental role is unclear. In the meanwhile, evidence has been provided for a high risk of developing malignancies in patients affected with Gaucher disease, the most common sphingolipidosis. This article aims at analyzing the potential involvement of lysosphingolipids in cancer. Knowledge about lysosphingolipids in the context of lysosomal storage diseases is summarized. Available data on the nature and prevalence of cancers in patients affected with sphingolipidoses are also reviewed. Then, studies investigating the biological effects of lysosphingolipids toward pro or antitumor pathways are discussed. Finally, original findings exploring the role of glucosylsphingosine in the development of melanoma are presented. While this lysosphingolipid may behave like a protumorigenic agent, further investigations in appropriate models are needed to elucidate the role of these peculiar lipids, not only in sphingolipidoses but also in malignant diseases in general.

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Section: Glcsph Promotes Necrosis and Produces Multinucleated Melanom...mentioning

confidence: 99%

Potential Role of Sphingolipidoses-Associated Lysosphingolipids in Cancer

Dubot

Astudillo

Therville

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

Skin and superficial soft tissue neoplasms with multinucleated giant cells: Clinical, histologic, phenotypic, and molecular differentiating features

Aramin

Zaleski

Prieto

et al. 2019

Annals of Diagnostic Pathology

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Intratumoral multinucleated giant cells are not a prognostic pathologic feature in cutaneous melanoma

Abstract: Despite prior anecdotal reports possibly linking multinucleated giant cells phenotype to more aggressive clinical course, we find that melanomas with multinucleated giant cells phenotype is not associated with shorter survival.

Cited by 4 publications

References 47 publications

Potential Role of Sphingolipidoses-Associated Lysosphingolipids in Cancer

Potential Role of Sphingolipidoses-Associated Lysosphingolipids in Cancer

Skin and superficial soft tissue neoplasms with multinucleated giant cells: Clinical, histologic, phenotypic, and molecular differentiating features

Atypical clear cell sarcoma of the pleura presenting as large pleural effusion with 22q12 abnormality: A challenging case with twists and turns

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