Intratumoral neutrophils: A poor prognostic factor for hepatocellular carcinoma following resection

Low Counts of γδ T Cells in Peritumoral Liver Tissue are Related to More Frequent Recurrence in Patients with Hepatocellular Carcinoma after Curative Resection

“…Our previous reports supported the relations between various immune cells (including regulatory T cells (Gao et al, 2007), memory T cells (Gao et al, 2012), dendritic cells (Cai et al, 2006), neutrophils (Li et al, 2011), mast cells (Ju et al, 2009), and activated hepatic stellate cells (Liao et al, 2013) in tumoral or peritumoral tissues with different survival outcomes. Our previous study also showed that the percentage of γδ T cells in HCC was reduced in tumor compared with peritumoral tissues and advanced tumor had even lower infiltration of γδ T cells, indicating the importance of γδ T cells in the antitumor immunity (Yi et al, 2013a).…”

“…Cox multivariate analysis was used to adjust for potentially confounding variables and to determine the independent prognostic factors. The "minimum P value" approach (Galon et al, 2006;Li et al, 2011) was used to get optimal cut-off value for the best separation between groups of patients related to TTR or OS. Significance was accepted when P < 0.05.…”

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

“…Hepatocellular carcinoma (HCC) The presence of intratumoral CD66 + neutrophils was a poor prognostic factor for HCC after resection [387] Hepatocellular carcinoma (HCC) Pre-operative NLR>5 was an adverse predictor of disease-free and overall survival. [148] Hepatocellular carcinoma (HCC) Patients with an NLR>2.5 showed higher risk for tumor recurrence in HCC patients undergoing liver transplantation.…”

Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of neutrophils toward an antitumor phenotype

“…An increased neutrophil-to-lymphocyte ratio and the presence of intratumoral neutrophils have been associated with a poor prognosis in several human studies. [6][7][8][9] Since cancer-related inflammation is recognized as a central mechanism of tumor progression, 10 neutrophils are considered a major player during carcinogenesis and tumor progression. 2 This discrepancy regarding the role of neutrophils in tumor immunology reflects the plasticity of neutrophils within the tumor microenvironment.…”