Intratympanic Steroid Injection for Treatment of Idiopathic Sudden Hearing Loss

Slattery, William H.; Fisher, Laurel M.; Iqbal, Zarina; Friedman, Rick A.; Liu, Naian

doi:10.1016/j.otohns.2005.05.015

Cited by 130 publications

(124 citation statements)

References 18 publications

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“…Since the etiology was not determined in most of the cases, the pathology is mostly known as idiopathic SSHL. Gender, regional differences, seasons, and smoking have no effect on the development of disease [1,4,5]. However, we have found 53.7% preponderance of male patient.…”

Section: Discussioncontrasting

confidence: 52%

The Significance of Routine Laboratory Parameters in Patients with Sudden Sensorineural Hearing Loss

Yasan

Tüz

Yariktaş

et al. 2012

Indian J Otolaryngol Head Neck Surg

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There are several factors (viral infections, metabolic and ototoxic disorders etc.) accused for the development of sudden sensorineural hearing loss. Some prognostic factors (late onset of treatment etc.) had been evaluated in the literature. There is no sufficient data on the effect of routine laboratory parameters on the development and/or prognosis of sudden sensorineural hearing loss. The aim of this study is to investigate the effects of routine blood chemistry and hematological parameters on the development and prognosis of disease in patients with idiopathic sudden sensorineural hearing loss. One hundred and forty-seven patients with the diagnosis of idiopathic sudden sensorineural hearing loss followed up during the periods of 2000-2010 years were included in this study.One hundred and three septoplasty patients with no otologic complaints were enrolled as control group. Following the clinical and demographic evaluations, patients with idiopathic sudden sensorineural hearing loss and control groups, and patients treated successfully and patients with poor outcome were compared with each other. Data were analyzed by T test. All hematological and biochemical parameters were compared. Hemoglobin, hematocrit, white blood cell count, total and direct bilirubin, fasting blood glucose level and aspartate aminotransferase were significantly different between idiopathic sudden sensorineural hearing loss and control groups. There was no significantly different parameter between patients treated successfully and patients with poor outcome. Hemoglobin, hematocrit, white blood cell count, total and direct bilirubin, fasting blood glucose level and AST all can be risk factors for SHL, or they can be the result of undetermined pathology, because these parameters have no effect on the prognosis. Other routine parameters seem to have no effect on the development and/or prognosis of idiopathic sudden sensorineural hearing loss.

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Section: Discussioncontrasting

confidence: 52%

The Significance of Routine Laboratory Parameters in Patients with Sudden Sensorineural Hearing Loss

Yasan

Tüz

Yariktaş

et al. 2012

Indian J Otolaryngol Head Neck Surg

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“…Other authors have also described the use of intratympanic corticosteroids for the treatment of SHL. 9,[12][13][14][15][16][17][18][19][20][21][23][24][25][26][27] Although its efficacy alone has not been proved definitively, intratympanic corticosteroid therapy for SHL is becoming more widely used. The variability among treatment protocols for SHL also applies to intratympanic corticosteroid therapy.…”

Section: Intratympanic Therapymentioning

confidence: 99%

“…13,15,16 Most studies about intratympanic corticosteroids for treating SHL report having attempted this mode of therapy after systemic corticosteroid therapy has failed. 9,[12][13][14][15][16][17][18][19][20][21][25][26][27] Two studies evaluated the effects of intratympanic corticosteroids as adjuvant therapy to systemic corticosteroids in SHL patients. 23,24 There are several advantages of using intratympanic corticosteroids (see Frame I).…”

Section: Intratympanic Therapymentioning

confidence: 99%

“…Administration modes also differ: transtympanic needle injection, 9,13,15,19,20,17,[24][25][26][27] myringotomy, 13,14 myringotomy with a ventilation tube, 12,23 myringotomy with a special perfusion needle (Micromedics, Eagan, MN), 18,21 and implantable infusion pumps in the middle ear (Round Window m-Cath; Durect Corp., Cupertino, CA) for continuous steroid release. 16,17,21 The duration of treatment, the interval between injections, and the number of injections also differs among authors, ranging from a single dose to weekly transtympanic injections, 9,12,14,15,18,20,23 steroid solutions as drops applied by patients during several weeks, 18,21 transtympanic injections several times a week, 19,23,25,26 or implantable infusion pumps. 16,17,21 Reported complications are rare, and include pain, 13 vertigo, 13,16,17,20,21 otitis media, 13 perforated tympanic membrane, 9,21 acne, 20 dysgeusia, …”

Section: Intratympanic Therapymentioning

confidence: 99%

“…Notwithstanding the high spontaneous recovery rates presented in some papers, our experience -and that of most authors -is that recovery of hearing is poor in patients that do not benefit from systemic corticoid therapy. 9,10 Several treatment protocols have been proposed for treating SHL. Corticosteroids, antiviral agents, anticoagulants, vasodilators, anti-inflammatory drugs, and other approaches have been suggested; there are reports of some benefit from most of these therapies.…”

Section: Introductionmentioning

confidence: 99%

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Metilprednisolona intratimpânica como terapia de resgate na surdez neurossensorial súbita

Raymundo¹,

Bahmad²,

Filho³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

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Treat ment in sudden sensorineural hearing loss is a contentious issue, today, oral steroids are the most common choice and considered the best treatment option, but the use of intratympanic steroids has become an attractive alternative, especially in cases when systemic therapy fails, or to avoid the side effects of the systemic use of steroids. Aim:To describe the results of intratympanic methylprednisolone in idiopathic sudden sensorineural hearing loss after failure of oral prednisolone.Methods: In a prospective study fourteen patients with idiopathic sudden sensorineural hearing loss were treated with intratympanic methylprednisolone after failing in the treatment with systemic steroids. Pretreatment and post-treatment audiometric evaluations including pure tone average (PTA) and speech reception thresholds (SRT) were analyzed. Results:Ten from 14 patients treated with intra-tympanic methylprednisolone presented with hearing recovery > 20 dB in PTA or 20% in SRT. Conclusion:Three intratympanic injections of methylprednisolone improved pure-tone average or speech discrimination scores for a subset of sudden hearing loss subjects that failed to benefit from oral steroids. Braz J Otorhinolaryngol. 2010;76(4):499-509. ORIGINAL ARTICLE BJORL

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Association of Vertigo With Hearing Outcomes in Patients With Sudden Sensorineural Hearing Loss

2018

JAMA Otolaryngol Head Neck Surg

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Intratympanic Steroid Injection for Treatment of Idiopathic Sudden Hearing Loss

Abstract: A clinical trial of intratympanic injections for idiopathic sudden hearing loss was successfully completed and promising results were found.

Cited by 130 publications

References 18 publications

The Significance of Routine Laboratory Parameters in Patients with Sudden Sensorineural Hearing Loss

The Significance of Routine Laboratory Parameters in Patients with Sudden Sensorineural Hearing Loss

Metilprednisolona intratimpânica como terapia de resgate na surdez neurossensorial súbita

Association of Vertigo With Hearing Outcomes in Patients With Sudden Sensorineural Hearing Loss

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