Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction

Abstract

Newcastle University ePrints-eprint.ncl.ac.uk Craciunas L, Tsampras N, Coomarasamy A, Raine-Fenning N. Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction.

Effect of intrauterine injection of human chorionic gonadotropin before fresh embryo transfer on IVF and ICSI outcomes: a meta-analysis

“…The dosages and types of hCG varied among the six RCTs. A meta-analysis published in 2016 found that a hCG dose of 500 IU or greater showed promise as the dosage before cleavage-stage ETs, but a hCG dose less than 500 IU before cleavage-stage ETs had no effect, and a dose of 500 IU or greater before blastocyst-stage ETs also showed no benefit [30]. Mansour’s study [3] reported that a 100- or 200 IU-hCG injection did not increase the pregnancy rate.…”

Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells

“…22 With the aim of increasing the success rate of IVF-ET, clinical trials examining intrauterine hCG administration have been conducted at various IVF centers. [23][24][25] However, there is no consensus regarding the level of efficacy or the most responsive patient populations to this treatment.…”

Novel predictive and therapeutic options for better pregnancy outcome in frozen embryo transfer cycles

“…Collectively, there are many reports to suggest that hCG may be a valuable adjuvant endometrial preparation agent; however, large‐scale trials are lacking. A 2018 Cochrane review designed to evaluate the impact of intrauterine infusion of hCG around the time of embryo transfer included data from 4751 sub‐fertile women in seventeen randomized controlled trials 74 . The overall findings of the review were limited secondary to significant study variation in hCG doses and timing of infusion.…”