Intrauterine administration of platelet-rich or -poor plasma to mitigate persistent breeding-induced endometritis (PBIE) of embryo donor mares

Segabinazzi, Lorenzo G.T.M.; Canisso, Igor F.; Podico, Giorgia; Leal, Luis; Novello, Guilherme; Barbosa, Lucélia Karoline Gonçalves; Rosser, Michael F.; Lima, F.S.; Alvarenga, Marco Antônio

doi:10.1016/j.jevs.2020.103083

Cited by 1 publication

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“…Platelet‐rich plasma has been shown to inhibit PMN migration and suppress the expression of proinflammatory cytokines such as IL‐1 and TNF‐α and downregulate intrauterine inflammation via decreased COX‐2 endometrial expression (Reghini et al, 2016; Segabinazzi et al, 2017). Moreover, PRP infusion was associated with higher embryo recovery rates (Segabinazzi et al, 2021) and improved chances of a successful pregnancy (Segabinazzi et al, 2020). An increase in up to 75% in the pregnancy rate in barren mares with chronic degenerative endometritis can be achieved (Carluccio et al, 2020).…”

Section: Prp and Endometritis In Animalsmentioning

confidence: 99%

Platelet‐rich plasma in animal reproductive medicine: Prospective and applications

Silviu‐Ionuț

Ibănescu²,

Alina

et al. 2022

Reprod Domestic Animals

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Platelet‐rich plasma (PRP) is the fraction of the plasma enriched with a platelet level above baseline, and it plays an essential role in tissue regeneration. The attention to PRP as unconventional therapy has increased during the past two decades. In animals, applications of PRP showed various degrees of success in a wide range of medical applications, from musculoskeletal injuries to ovarian insufficiency. Therapeutic applications with PRP in farm animals are still scarce, but the promising results offered by several studies are expected to trigger more interest in its application by both veterinarians and farmers. In this review, we highlight some efforts made in the field of animal reproduction regarding the use of PRP to potentiate the ovarian hypofunction, treat endometritis, improve the follicular development, oocyte competence and uterine environment for embryo implantation as well as restore testicular and erectile function in male, and as a treatment for mastitis.

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