Intrauterine development of posthaemorrhagic hydrocephalus

Leidig, E; Dannecker, Günther; Pfeiffer, K. H.; Salinas, R.; Peiffer, J.

doi:10.1007/bf00442606

Cited by 32 publications

(9 citation statements)

References 9 publications

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“…This association is not uncommon [4][5][6][7][8][9][10] , and it is usually explained on the basis of hypoxia leading to both IUGR and intracerebral circulatory changes with secondary hemorrhage 4 . However, it might also be hypothesized that 33 .…”

Section: Discussionmentioning

confidence: 99%

“…As many of these cases were associated with placental abruption 2,3 or intrauterine growth restriction (IUGR) [4][5][6][7][8][9][10] , the same hypoxic / asphyctic pathogenesis that is often relevant in newborns was hypothesized to be so also in fetuses. In other cases, fetal intracranial hemorrhage has been linked to fetal thrombocytopenia 7,11 or coagulation disorders 12 -14 . Hemorrhage in a subdural location has been mainly related to maternal trauma, often also causing uteroplacental or other fetal injuries 15 .…”

Section: Introductionmentioning

confidence: 99%

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Fetal intracranial hemorrhage: is minor maternal trauma a possible pathogenetic factor?

Strigini

Cioni

Canapicchi

et al. 2001

Ultrasound in Obstet & Gyne

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fetal intracranial hemorrhage: is minor maternal trauma a possible pathogenetic factor?

Strigini

Cioni

Canapicchi

et al. 2001

Ultrasound in Obstet & Gyne

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“…1983, Bondurant et al 1984, Donn et al 1984, McGahan el al. 1984, Sims et al 1985, Ellis et al 1988, Leidig et al 1988, as well as soon after birth (de Crespigny et al 1982, Dilfin et al 1983, Beverley et al 1984. Although hemorrhages evident at different ages share many risk factors, preliminary analyses have led us to view early-onset (before 12th postnatal hour) germinal matrix hemorrhage (EGMH) as etiologically distinct from later-onset germinal matrix hemorrhage .…”

mentioning

confidence: 99%

The Epidemiology of Germinal Matrix Hemorrhage During the First Half‐day of Life

Leviton

Pagano

Kuban

et al. 1991

Develop Med Child Neuro

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SUMMARY The personal and maternal characteristics of 27 babies with early‐onset germinal matrix hemorrhage (EGMH) were compared with those of 280 babies with normal cranial ultrasonograms, studied in a separate clinical trial. None of the mothers of the babies with EGMH had high blood pressure or pre‐eclampsia during pregnancy. Gestational age <30 weeks and initial pH <7·2 indicated increased risks of EGMH, and maternal receipt of steroids indicated reduced risk of EGMH. Thus prenatal and immediately perinatal factors appear to convey much of the information about the risk of EGMH. RÉSUMÉ Epidémiologie des hémorragies manifestes de la couche germinative durant la première demi‐journée de vie Les caractéristiques personnelles et maternelles de 27 nourrissons présentant une hémorragie précoce de la couche germinative (EGMH) ont été comparées à celles de 280 nourrissons avec échographies craniennes normales, observés dans un service clinique séparé. Aucune des mères n'avait présenté d'hypertension artérielle ou d'éclampsie durant la grossesse. Un âge conceptuel de moins de 30 semaines et un pH initial inférieur à 7,2 traduisaient un risque accru et l'administration de corticoïdes stéroïdiens a la mère, un risque diminué d'EGMH. Ainsi, les facteurs prénataux et périnataux précoces paraissent fournir l'essentiel de l'information sur le risque d'EGMH. ZUSAMMENFASSUNG Die Epidemiologie von Keimschichtblutungen in den ersten Lebensstunden Von 27 Babies mit früh auftretender Keimschichtblutung (EGMH) wurden die kindlichen und mütterlichen Befunde mit denen von 280 Babies mit normalen cranialen Ultraschallbefunden, die gesondert untersucht wurden, verglichen. Keine der Mütter hatte einen hohen Blutdruck oder eine Praeeklampsie in der Schwangerschaft. Ein Gestationsalter <30 Wochen und ein initialer pH Wert <7·2 bedeutete ein erhöhtes Risiko und eine Steroidtherapie der Mutter ein vermindertes Risiko für EGMH. So scheinen pränatale und perinatale Faktoren viel über das Risiko der EGMH auszusagen. RESUMEN Epidemiologie de la hemorragia de la martiz ferminal evidente durante el primer medio año de vida Se compararon las caractersticas personales y maternas de veintisiete lactantes con hemorragia precoz de la matriz germinal (HPMG), con las de 280 lactantes con ultrasonografia craneal normal, estudiados em dos grupos clinicos separados. Ninguna de las madres habia tenido hipertensión o preeclamsia durante el embarazo. Una edad de gestacion de menos de 30 semanas y un pH inicial inferior a 7,2 indicaban un aumento de riesgo y la recepción materna de esteroides indicaba un riesgo reducido de HPMG. Asi pues, los factores prenatales e inmediatamente perinatales se muestran como indicadores de una gran parte de la información acerca del riesgo de HPMG.

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“…The causes of fetal hydrocephalus are varied and have prognostic significance (5,32). In utero hydrocephalus as a consequence of identifiable hemorrhage has been well documented, the majority in the third trimester by readily identifiable hemorrhagic lesions (14,18,25,31,37). Cryptic intracerebral hemorrhage has been postulated as a cause of fetal hydrocephalus (8,10,12); however, by definition, it cannot be diagnosed by current ultrasound examination techniques.…”

Section: Introductionmentioning

confidence: 99%

Fetal Hydrocephalus Caused by Cryptic Intraventricular Hemorrhage

Lategan¹,

Chodirker

Bigio³

2010

Brain Pathology

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Cryptic intracerebral hemorrhage as an etiological factor in fetal hydrocephalus has been postulated but not described at autopsy. Four fetuses with overt hydrocephalus diagnosed by in utero ultrasound examination were examined at autopsy at 19-22 weeks gestation. Although a hemorrhagic etiology was not evident on ultrasound, hemosiderin-containing macrophages and associated reactive changes were found to obstruct the otherwise well-formed cerebral aqueduct in all four. Coagulopathy due to thrombocytopenia was implicated in one case. Anomalies involving other parts of the body were identified in two cases, although a direct link to the hydrocephalus was not obvious. The abnormality was isolated in one case. In three cases, possible sites of hemorrhage in the ventricles were identified. This abnormality represents a significant proportion of the fetuses examined for hydrocephalus in our referral center. We discuss the importance of careful autopsy examination in the diagnosis of cryptic intracerebral hemorrhage and the implications for counseling.

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Intrauterine development of posthaemorrhagic hydrocephalus

Cited by 32 publications

References 9 publications

Fetal intracranial hemorrhage: is minor maternal trauma a possible pathogenetic factor?

Fetal intracranial hemorrhage: is minor maternal trauma a possible pathogenetic factor?

The Epidemiology of Germinal Matrix Hemorrhage During the First Half‐day of Life

Fetal Hydrocephalus Caused by Cryptic Intraventricular Hemorrhage

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