Intravascular Hemolysis From A Clostridium Perfringens Liver Abscess

Kreidl, Ken O; Green, G.Randall; Wren, Sherry M.

doi:10.1016/s1072-7515(01)01169-3

Cited by 31 publications

(16 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Upon germination, however, rapid growth may be advantageous to repopulate the niche. Indeed, the ten minute replication time of some spore-forming species of the clostridia bacteria are among the fastest known (Kreidl et al, 2002). …”

Section: Three Strategies To Weather the Stormmentioning

confidence: 99%

The Normalcy of Dormancy: Common Themes in Microbial Quiescence

Rittershaus

Baek

Sassetti

2013

Cell Host & Microbe

300

267

View full text Add to dashboard Cite

All microorganisms are exposed to periodic stresses that inhibit growth. Many bacteria and fungi weather these periods by entering a hardy, non-replicating state, often termed quiescence or dormancy. When this occurs during an infection, the resulting slowly-growing pathogen is able to tolerate both immune insults and prolonged antibiotic exposure. While the stresses encountered in a free-living environment may differ from those imposed by host immunity, these growth-limiting conditions impose common pressures and many of the corresponding microbial responses appear to be universal. In this review, we discuss the common features of these growth-limited states, which suggest new approaches for treating chronic infections such as tuberculosis.

show abstract

Section: Three Strategies To Weather the Stormmentioning

confidence: 99%

The Normalcy of Dormancy: Common Themes in Microbial Quiescence

Rittershaus

Baek

Sassetti

2013

Cell Host & Microbe

300

267

View full text Add to dashboard Cite

show abstract

“…Intravenous injection of ␣-toxin into mice resulted in massive intravascular hemolysis (Sugahara and Osaka, 1970;Kreidl et al, 2002). To investigate the effect of ERM and KTM on the intravascular hemolysis induced by ␣-toxin, mice preinjected with ERM and KTM were i.v.…”

Section: Effect Of Macrolide Antibiotics On Lethalitymentioning

confidence: 99%

Effect of Erythromycin on Biological Activities Induced byClostridium perfringensα-Toxin

Oda

Kihara²,

Yoshioka³

et al. 2008

J Pharmacol Exp Ther

View full text Add to dashboard Cite

show abstract

“…It has a strong proliferation proportion, by doubling in number within 7 minutes [1]. It secretes many toxins involved in the hemolysis.…”

Section: Discussionmentioning

confidence: 99%

Acute Hemolysis in the Emergency Department: Think aboutClostridium perfringens!

Cécilia

Baptiste

Clouzeau

et al. 2013

Case Reports in Emergency Medicine

View full text Add to dashboard Cite

Clostridium perfringens (CP) gives several clinical settings, from an asymptomatic to a massive intravascular hemolysis. We report a case of fatal intravascular hemolysis due to CP septicemia having a hepatic supposed starting point in the emergency department. Like in many cases, the diagnosis was made when patient had already gone into shock and died. The CP septicemia often complicated the course of the digestive or genital pathologies. The alpha toxin can damage the structural integrity of the red cell membrane by means of a phospholipase activity. Nevertheless, a massive intravascular hemolysis arises only rarely in this septicemia, only from 7 to 15% of the cases. The emergency physician has to think about this complication in case of hemoglobinuria and/or signs of hemolysis associated with a septic syndrome. An immediate antibiotic treatment adapted as well as the symptomatic treatment of the spread intravascular coagulation could improve the survival of these patients.

show abstract

Intravascular Hemolysis From A Clostridium Perfringens Liver Abscess

Cited by 31 publications

References 3 publications

The Normalcy of Dormancy: Common Themes in Microbial Quiescence

The Normalcy of Dormancy: Common Themes in Microbial Quiescence

Effect of Erythromycin on Biological Activities Induced byClostridium perfringensα-Toxin

Acute Hemolysis in the Emergency Department: Think aboutClostridium perfringens!

Contact Info

Product

Resources

About