Intravascular Imaging of the Vulnerable Atherosclerotic Plaque: Spotlight on Temperature Measurement

Verheye, Stefan; Diamantopoulos, Leonidas; Serruys, Patrick W.; Langenhove, Glenn Van

doi:10.1177/174182670200900504

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…The quantity of MA-ce 6 in the tissue sample was determined by multiplying the fluorescence emission by a constant determined from calibration curves prepared from known amounts of either MA-ce6 or free ce6 homogenized with similar weights of nonfluorescent arterial tissue. The tissue concentration of MA-ce 6 was expressed as moles of equivalent per gram of tissue.…”

Section: Photosensitizer Extraction Frommentioning

confidence: 99%

“…3 These detection methods include both invasive modalities that require cardiac catheterization and noninvasive imaging methods. Examples of the former invasive techniques include intravascular ultrasound, 4 optical coherence tomography, 5 intravascular thermography, 6 and near-infrared spectroscopy. 7 Examples of noninvasive techniques include multislice x-ray computed tomography, 8 magnetic resonance imaging, 9 electron-beam imaging of calcium deposits, 10 and 2-[18F] fluoro-2-deoxy-D-glucose mediated positron emission tomography.…”

Section: Introductionmentioning

confidence: 99%

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Photosensitizer delivery to vulnerable atherosclerotic plaque: comparison of macrophage-targeted conjugate versus free chlorine(e6)

et al. 2006

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We have previously shown that a conjugate (MA-ce6) between maleylated serum albumin and the photosensitizer chlorin(e6) (ce6) is targeted in vitro to macrophages via class A scavenger receptors. We now report on the ability of this conjugate to localize in macrophage-rich atherosclerotic plaques in vivo. Both the conjugate and the free photosensitizer ce6 are studied after injection into New Zealand White rabbits that are rendered atherosclerotic by a combination of aortic endothelial injury and cholesterol feeding into normal rabbits. Rabbits are sacrificed at 6 and 24 h after injection and intravascular fluorescence spectroscopy is carried out by fiber-based fluorimetry in intact bloodfilled arteries. Surface spectrofluorimetry of numbered excised aortic segments together with injured and normal iliac arteries is carried out, and quantified ce6 content by subsequent extraction and quantitative fluorescence determination of the arterial segments and also of nontarget organs. There is good agreement between the various techniques for quantifying ce6 localization, and high contrast between arteries from atherosclerotic and normal rabbits is obtained. Fluorescence correlates with the highest burden of plaque in the aorta and the injured iliac artery. The highest accumulation in plaques is obtained using MA-ce6 at 24 h. Free ce6 gives better accumulation at 6 h compared to 24 h. The liver, spleen, lung, and gall bladder have the highest uptake in nontarget organs. Macrophagetargeted photosensitizer conjugates may have applications in both detecting and treating inflamed vulnerable plaque.

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Section: Photosensitizer Extraction Frommentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photosensitizer delivery to vulnerable atherosclerotic plaque: comparison of macrophage-targeted conjugate versus free chlorine(e6)

et al. 2006

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show abstract

“…Increased metabolic activity of macrophages, exothermal processes concerning the enzymatic extracellular matrix degradation and lipid metabolism are suggested reasons for the increased temperatures (Verheye et al, 2002a;Zarrabi et al, 2002;ten Have et al, 2005).…”

Section: Introductionmentioning

confidence: 96%