Intravenous adenosine in the treatment of supraventricular tachycardia: a dose‐ranging study and interaction with dipyridamole.

Watt, Andrew; Bernard,; Webster, John H.; Passani, SL; Stephens,; Routledge, PA

doi:10.1111/j.1365-2125.1986.tb05180.x

Cited by 65 publications

(16 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ATP was shown to evoke transient tachycardia at low doses and to induce AV block at high doses [659,660]. Later, adenosine was also found to be effective in the acute termination of PSVT [661,662] and was used effectively in children [663][664][665][666]. The mechanism of terminating the arrhythmias by either adenosine or ATP is the induction of transient complete AV nodal conduction block.…”

Section: Arrhythmiasmentioning

confidence: 99%

Cardiac purinergic signalling in health and disease

Burnstock

Pelleg

2014

Purinergic Signalling

120

View full text Add to dashboard Cite

This review is a historical account about purinergic signalling in the heart, for readers to see how ideas and understanding have changed as new experimental results were published. Initially, the focus is on the nervous control of the heart by ATP as a cotransmitter in sympathetic, parasympathetic, and sensory nerves, as well as in intracardiac neurons. Control of the heart by centers in the brain and vagal cardiovascular reflexes involving purines are also discussed. The actions of adenine nucleotides and nucleosides on cardiomyocytes, atrioventricular and sinoatrial nodes, cardiac fibroblasts, and coronary blood vessels are described. Cardiac release and degradation of ATP are also described. Finally, the involvement of purinergic signalling and its therapeutic potential in cardiac pathophysiology is reviewed, including acute and chronic heart failure, ischemia, infarction, arrhythmias, cardiomyopathy, syncope, hypertrophy, coronary artery disease, angina, diabetic cardiomyopathy, as well as heart transplantation and coronary bypass grafts.

show abstract

Section: Arrhythmiasmentioning

confidence: 99%

Cardiac purinergic signalling in health and disease

Burnstock

Pelleg

2014

Purinergic Signalling

120

View full text Add to dashboard Cite

show abstract

“…During our initial evaluation of adenosine for treatment of this arrhythmia in man (Watt et al, 1985) we observed that adenosine produced hyperpnoea at about the time that it exerted its cardiac electrophysiological effects (unpublished observations). In a subsequent study of the negative chronotropic effects of adenosine on the hearts of normal volunteers we observed that adenosine was a powerful but short-lived subjective respiratory stimulant (unpublished observations).…”

Section: Introductionmentioning

confidence: 99%

Adenosine stimulates respiration in man.

Watt¹,

Routledge²

1985

Brit J Clinical Pharma

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although adenosine may have intrinsic anticonvulsant activity,9,15,69, it does not cross the blood-brain barrier, 71 but analogues of adenosine capable of entering the brain might be potentially useful. Whilst intravenous bolus doses of adenosine have been used to terminate paroxysmal tachycardias in patients, 11,12,14,27,72,73 there are no data on the effect of adenosine in theophylline-induced tachycardias. Bolus doses of adenosine are now used as an antiarrhythmic as they produce a transiently high local concentration of adenosine at the sinoatrial node.29 Thus, a single bolus dose of adenosine might be sufficient to abort an episode of supraventricular tachycardia due to theophylline.…”

Section: Discussionmentioning

confidence: 99%

Pharmacodynamic Interactions Between Infused Adenosine and Oral Theophylline

Minton

Henry

1991

Hum Exp Toxicol

View full text Add to dashboard Cite

1 Five healthy human subjects were given, in single-blind fashion, either (a) 625 mg theophylline orally, followed 4 h later, by a 40 min infusion of adenosine (40 μg kg -1 min-1 for 5 min, 60 μg kg-1 min -1 for 5 min and 80 μg kg-1 min-1 for 30 min), or (b) 625 mg theophylline orally followed by 0.9% sodium chloride infusion, or (c) placebo theophylline tablets followed by adenosine infusion. 2 All five subjects experienced adverse effects during adenosine infusion, mainly at the higher infusion rates; two subjects also experienced chest pain but not during combined treatment with theophylline and adenosine. 3 Diastolic blood pressure (DBP) rose by 16.5 mmHg ( P < 0.001) following treatment with theophylline only, fell by 24.5 mmHg ( P < 0.001) during the adenosine infusion after placebo theophylline and remained unchanged during the adenosine infusion following theophylline. Pulse rate rose by 12 min -1 ( P < 0.01) during adenosine infusion following placebo, but not after theophylline alone or theophylline and adenosine combined. 4 The respiratory rate fell by 6 min-1 ( P < 0.01) during treatment with adenosine only, being lower than for the two treatments containing theophylline ( P < 0.05). 5 Plasma potassium and magnesium fell by 0.25 mmol I-1 ( P < 0.001) and 0.037 mmol I-1 ( P < 0.05), respectively, during treatment with theophylline only, but these effects were not altered by infusion of adenosine. 6 This study has demonstrated interactions between theophylline and adenosine on diastolic blood pressure and respiratory rate, but no interaction on metabolic parameters. Adenosine infusion is unlikely to be of value in the management of theophylline toxicity, but its effects on theophylline-induced cardiac arrhythmias remain unexplored.

show abstract

Intravenous adenosine in the treatment of supraventricular tachycardia: a dose‐ranging study and interaction with dipyridamole.

Cited by 65 publications

References 8 publications

Cardiac purinergic signalling in health and disease

Cardiac purinergic signalling in health and disease

Adenosine stimulates respiration in man.

Pharmacodynamic Interactions Between Infused Adenosine and Oral Theophylline

Contact Info

Product

Resources

About