Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats

Updates in the pathophysiological mechanisms of Parkinson’s disease: Emerging role of bone marrow mesenchymal stem cells

“…In the light of our results, treatment with BM-MSCs caused insignificant increase in the number of positive cells for survivin expression. This increment is in agreement with Okazaki et al [79] and it could be imputed to the ability of MSCs to enhance neurogenesis and inhibit apoptosis through their secreted BDNF as documented by Ye et al [72] . Moreover, Kim et al [80] reported that grafted MSCs attenuate dopaminergic neuronal loss through their antiapoptotic effects.…”

Mesenchymal stem cells as a treatment for neonatal ischemic brain damage

“…Administration of MSCs 3 to 24 h after stroke in adult animals reduced the number of apoptotic cells by approximately 50% in the ischemic boundary zone, which was accompanied by an increased expression of antiapoptotic proteins Bcl-2 and survivin (5). These results indicate that transplantation of MSCs in the very early phase after ischemic brain injury is neuroprotective and thereby improves functional outcome.…”

“…Mesenchymal stem cells (MSCs) can also be neuroprotective because the cells have important anti-inflammatory and antiapoptotic properties (5)(6)(7)(8). Administration of MSCs 3 to 24 h after stroke in adult animals reduced the number of apoptotic cells by approximately 50% in the ischemic boundary zone, which was accompanied by an increased expression of antiapoptotic proteins Bcl-2 and survivin (5).…”

Isolation and Characteristics of Mesenchymal Stromal Cells from Different Parts of Placenta

“…Probably, the banking and followed by clinical application of mixed population of maternal and fetal MSCs will potentially lead to a greater and interesting therapeutic effect. Further research is needed to verify this hypothesis [23][24][25][26][27][28][29][30][31].…”