Intravenous Administration of Scutellarin Nanoparticles Augments the Protective Effect against Cerebral Ischemia–Reperfusion Injury in Rats

Yang, Chang; Zhao, Qing; Yang, Shanshan; Wang, Yunlong; Xu, Xun; Li, Lisu; Al-Jamal, Wafa' T

doi:10.1021/acs.molpharmaceut.1c00942

Cited by 11 publications

(6 citation statements)

References 49 publications

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“…These differential metabolites, mainly including phenolic acids, iridoids, and flavonoids, were the active compounds of honeysuckle [ 59 ]. They have active phenolic hydroxyl and are prone to oxidizing and polymerizing to produce some dark compounds under the influence of environmental factors and the action of related enzymes [ 60 , 61 ]. Subsequently, these reactions lead to the darkening or fading of honeysuckle samples.…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Quality Analysis of Different Colors of Medicinal and Edible Honeysuckle

Liu,

Cheng,

Chao

2023

Foods

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Honeysuckle (the dried flower bud or opening flower of Lonicera japonica Thunb.), a medicinal and edible substance, has is greatly popular among consumers for its remarkable health effects, such as antioxidant, antibacterial, and anti-inflammatory effects. However, due to the influences of processing methods, storage conditions, and other factors, honeysuckles show different colors which can directly reflect the quality and the price on the market. In order to comprehensively compare the quality of different colors, 55 batches of honeysuckle samples were collected and analyzed. Their color parameters, chlorophyll content (chl), total phenol content (TPC), total flavonoid content (TFC), antioxidant activity (AA), main active compounds, and metabolites were measured. As a result, the initial green-white (GW) samples, a kind of highest-quality honeysuckle, had the smallest a* value, largest h*, chl, TPC, TFC, and AA values, and highest content of chlorogenic acid and cynaroside. There was a significant difference between GW samples and a series of discolored samples. As the color darkened or lightened, the quality gradually decreased. The yellow-brown (YB) samples were of the worst quality and were no longer available for clinical and health purposes. A series of differential metabolites, such as quercetin-7-O-glucoside and secologanoside, could be used as important references to evaluate the quality of differently colored samples. The metabolic profile of honeysuckle provided new insights into the process of color change and laid a foundation for further honeysuckle quality control. The correlation results showed that the a* and h* values significantly affect the abovementioned quality indicators and the 10 main active compounds. In other words, the color difference could directly reflect the quality and clinical efficacy. Multiple regression analysis was carried out using combined L*, a*, and b* values to predict the quality of honeysuckle. This is the first time the quality of different color honeysuckle samples on the post-harvest link has been systematically compared and a demonstration of medicinal and edible substances with different colors has been provided.

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Section: Discussionmentioning

confidence: 99%

A Comprehensive Quality Analysis of Different Colors of Medicinal and Edible Honeysuckle

Liu,

Cheng,

Chao

2023

Foods

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“…The volume of the infarction was determined using triphenyltetrazolium chloride (TTC) staining in 24 out of the total 38 evaluated studies. Compared to the control groups, the group treated with nanoparticles showed a significant reduction in the infarct area, with the reduction scaling up to 80% depending on the dosage [ 12 , 13 , 16 , 17 , 18 , 20 , 21 , 23 , 24 , 25 , 26 , 27 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 40 , 41 , 42 , 43 , 44 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…The evaluation of neurological recuperation was carried out using behavioral metrics in a significant portion of the included studies (68.42%). Several tests were employed in this regard, including the adhesive removal (or sticky tape) test, the beam walk test, the rotarod performance test, the cylinder test, and the grid walking test, to name a few [ 12 , 13 , 15 , 16 , 17 , 18 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Nanodrugs for the Treatment of Ischemic Stroke: A Systematic Review

Ruscu

Cercel

Kılıç

et al. 2023

IJMS

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Ischemic stroke, a significant neurovascular disorder, currently lacks effective restorative medication. However, recently developed nanomedicines bring renewed promise for alleviating ischemia’s effects and facilitating the healing of neurological and physical functions. The aim of this systematic review was to evaluate the efficacy of nanotherapies in animal models of stroke and their potential impact on future stroke therapies. We also assessed the scientific quality of current research focused on nanoparticle-based treatments for ischemic stroke in animal models. We summarized the effectiveness of nanotherapies in these models, considering multiple factors such as their anti-inflammatory, antioxidant, and angiogenetic properties, as well as their safety and biodistribution. We conclude that the application of nanomedicines may reduce infarct size and improve neurological function post-stroke without causing significant organ toxicity.

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“…On the contrary, both SCU groups showed a better performance since lower neurological scores were recorded in the diseased rats treated with SCU-PLGA NPs (1.33 ± 0.52) and free SCU (1.83 ± 0.41); the former was lower than the latter. The infarct size of the sick rats treated with SCU-PLGA NPs (19%) was smaller than that of the rats treated with free SCU (27%) [ 68 ]. It was also observed that SCU-PLGA NPs greatly extended the release curve and blood circulation duration of SCU, as well as preventing nerve cell apoptosis, as shown in Figure 4 .…”

Section: Applications Of Plga-based Nanostructures In Drug Delivery A...mentioning

confidence: 99%

“…Data shown as mean ± SD. Adapted with permission from [ 68 ]. Copyright (2022) American Chemical Society.…”

Section: Figurementioning

confidence: 99%

The Recent Applications of PLGA-Based Nanostructures for Ischemic Stroke

Yan,

Huang,

Feng

et al. 2023

Pharmaceutics

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With the accelerated development of nanotechnology in recent years, nanomaterials have become increasingly prevalent in the medical field. The poly (lactic acid–glycolic acid) copolymer (PLGA) is one of the most commonly used biodegradable polymers. It is biocompatible and can be fabricated into various nanostructures, depending on requirements. Ischemic stroke is a common, disabling, and fatal illness that burdens society. There is a need for further improvement in the diagnosis and treatment of this disease. PLGA-based nanostructures can facilitate therapeutic compounds’ passage through the physicochemical barrier. They further provide both sustained and controlled release of therapeutic compounds when loaded with drugs for the treatment of ischemic stroke. The clinical significance and potential of PLGA-based nanostructures can also be seen in their applications in cell transplantation and imaging diagnostics of ischemic stroke. This paper summarizes the synthesis and properties of PLGA and reviews in detail the recent applications of PLGA-based nanostructures for drug delivery, disease therapy, cell transplantation, and the imaging diagnosis of ischemic stroke.

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Intravenous Administration of Scutellarin Nanoparticles Augments the Protective Effect against Cerebral Ischemia–Reperfusion Injury in Rats

Cited by 11 publications

References 49 publications

A Comprehensive Quality Analysis of Different Colors of Medicinal and Edible Honeysuckle

A Comprehensive Quality Analysis of Different Colors of Medicinal and Edible Honeysuckle

Nanodrugs for the Treatment of Ischemic Stroke: A Systematic Review

The Recent Applications of PLGA-Based Nanostructures for Ischemic Stroke

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