Intravenous Branched Chain Amino Acid Trial in Marrow Transplant Recipients

Lenssen, P.; Cheney, C. L.; Aker, S. N.; Cunningham, B. A.; Darbinian, J.; Gauvreau, J. M.; Barale, K. V.

doi:10.1177/014860718701100202

Cited by 3 publications

(7 citation statements)

References 8 publications

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“…So termination of PN may result in loss of weight and muscle mass. 6,21 Hematologic outcomes Our study showed that time to platelet engraftment was shorter in group A than group B. It was revealed in murine studies that engraftment was better with feeding than with fasting.…”

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confidence: 70%

“…Because such infections are usually treatable bacterial infections, in contrast to fungal and viral infections, which usually occur after engraftment and discontinuation of PN. 6,21 In addition, chemotherapy, radiotherapy and medicine prescribed to hematopoietic SCT patients may suppress the immune system, which renders hematopoietic SCT patients prone to infection. On the other hand, because of buccal mucositis, esophagitis and enteritis, hematopoietic SCT patients are unable to tolerate oral intake.…”

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confidence: 99%

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Clinical effect of individualized parenteral nutrition vs conventional method in patients undergoing autologous hematopoietic SCT

Tavakoli-Ardakani

Neman

Mehdizadeh

et al. 2013

Bone Marrow Transplant

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Malnutrition in patients undergoing hematopoietic SCT is known as a risk factor for adverse effects and is directly or indirectly responsible for excess mortality and morbidity. We designed the present study to evaluate the effects of individualized parenteral nutrition (PN) and compare the present method to the conventional PN. Individualized PN based on the Harris À Benedict equation was administered to 30 patients after hematopoietic SCT and was compared with an age, gender and disease matched group of patients who underwent hematopoietic SCT with conventional PN. These two groups were compared on clinical, hematological, nutritional outcomes. Comparing duration of hospital stay (P valueo0.0001), infection (P value ¼ 0.01), time to platelet engraftment (P value ¼ 0.02), units of packed cell transfusion (P value ¼ 0.006) and decrease in body weight (P value ¼ 0.004) showed significant differences between the two groups. In conclusion, the use of individualized PN seems more beneficial than conventional PN.Bone Marrow Transplantation (2013) 48, 958-962;

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confidence: 70%

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confidence: 99%

Clinical effect of individualized parenteral nutrition vs conventional method in patients undergoing autologous hematopoietic SCT

Tavakoli-Ardakani

Neman

Mehdizadeh

et al. 2013

Bone Marrow Transplant

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“…Based on this premise, numerous projects studying the effect of BCAA in the critically ill have been published [1][2][3][4][5][6][7][11][12][13][14][15][16][17]. A majority of these studies have used nitrogen balance as their gold standard in terms of evaluating the benefit of BCAA.…”

Section: Discussionmentioning

confidence: 99%

“…A majority of these studies have used nitrogen balance as their gold standard in terms of evaluating the benefit of BCAA. With this as a criterion, several studies have shown a positive effect for BCAA in critically ill patients [1][2][3][4][5][6][7], while others have shown no beneficial effects [11][12][13][14][15][16][17]. It is worth noting that in none of these studies were detrimental effects of BCAA documented.…”

Section: Discussionmentioning

confidence: 99%

“…However, some animal studies have failed to show a significant effect of BCAA on nitrogen balance [8][9][10]. Perhaps more importantly, numerous human studies have also shown equivocal results in this regard [11][12][13][14][15][16][17]. In a randomized, crossover, 8-day study of 10 critically ill patients by Vanderwoude et al, there was no significant difference between standard total parenteral nutrition (TPN) solutions and BCAA-supplemented solutions with respect to nitrogen balance [16].…”

Section: Introductionmentioning

confidence: 99%

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Failure of BCAA supplementation to promote nitrogen retention in injured patients.

Scholten

Morgan

Davis³

et al. 1990

Journal of the American College of Nutrition

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The purpose of this study was to determine if supplementing total parenteral nutrition (TPN) with lipids or the branched chain amino acids (BCAA) leucine, isoleucine, and valine influences nitrogen balance in the injured patient. Four TPN study solutions were used, with each patient receiving two of the solutions for 4 days each. Group A received solutions consisting of 19% and 44% BCAA, with nonnitrogen calories supplied by 100% carbohydrate. Group B received a 7:3 carbohydrate-to-lipid ratio of nonnitrogen calories as a fuel source. Neither BCAA supplementation nor varying fuel substrates promoted a difference in nitrogen retention. The added cost of BCAA supplementation, along with the lack of an effect upon nitrogen accretion, indicates that greater benefits must be demonstrated before widespread use of BCAA supplementation can be recommended in the injured patient.

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Branched‐chain amino acids

Platell

Kong

Mccauley³

et al. 2000

J of Gastro and Hepatol

123

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The branched‐chain amino acids (BCAA), isoleucine, leucine and valine, are unique in that they are principally metabolized extrahepatically in the skeletal muscle. This observation led to the investigation of these nutrients in a number of clinical scenarios. By far the most intensively studied applications for BCAA have been in patients with liver failure and/or patients in catabolic disease states. However, the resulting studies have not demonstrated a clear clinical benefit for BCAA nutritional supplements. In patients with liver failure, the BCAA did improve nitrogen retention and protein synthesis, but their effect on patient outcome was less clear. Similarly, in critically ill septic patients, BCAA did not improve either survival or morbidity. The BCAA are important nutrients, and it seems that any specific benefits associated with their use will be based upon a greater understanding of the underlying cellular biology. Potential areas of further research may include the combination of BCAA supplements with other anabolic factors (e.g. growth hormone) in managing patients with catabolic disease states.

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Intravenous Branched Chain Amino Acid Trial in Marrow Transplant Recipients

Cited by 3 publications

References 8 publications

Clinical effect of individualized parenteral nutrition vs conventional method in patients undergoing autologous hematopoietic SCT

Clinical effect of individualized parenteral nutrition vs conventional method in patients undergoing autologous hematopoietic SCT

Failure of BCAA supplementation to promote nitrogen retention in injured patients.

Branched‐chain amino acids

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