Intravenous Dolasetron for the Prevention of Postoperative Nausea and Vomiting After Outpatient Laparoscopic Gynecologic Surgery

Anesthesia for laparoscopy: a review

“…Ondansetron given at the end of surgery results in a significantly greater antiemetic effect, compared with preinduction dosing [99]. Dolasetron and granisetron, other 5-HT3 antagonists, are effective as well [100,101].…”

RETRACTED ARTICLE: Current prevention and treatment of postoperative nausea and vomiting with 5-hydroxytryptamine type 3 receptor antagonists: a review

“…and orally, has been evaluated for the prevention and treatment of PONV. Graczyk et al [60] have compared the efficacy and safety of i.v. dolasetron at three different doses (12.5, 25, and 50 mg) for the prevention of PONV after outpatient laparoscopic gynecologic surgery, and have determined that dolasetron 12.5 mg is the minimum effective dose.…”

Timing of administration of dolasetron affects dose necessary to prevent postoperative nausea and vomiting

“…Patients enrolled in the pooled studies were similar based on baseline demographic and clinical characteristics ( Table 2 [11][12][13][14][15][16][17][18] ), as would be expected based on common inclusion criteria. The mean age of enrolled patients treated with dolasetron or placebo ranged from 32 to 43 years.…”

“…Those with significant cardiac or hepatic disease, those who vomited or received any drug with antiemetic activity within 24 hours of surgery, or who were scheduled for gastric suctioning during or after surgery were excluded from enrollment. Four of the six trials that evaluated dolasetron for prevention of PONV included only females undergoing gynecologic surgery; two of the PONV prevention trials and both PONV treatment trials enrolled both males and females undergoing various surgical procedures ( Table 1 [11][12][13][14][15][16][17][18] ).…”