Intravenous immunoglobulin for presumed viral myocarditis in children and adults

Robinson, Joan; Hartling, Lisa; Vandermeer, Ben; Klassen, Terry P

doi:10.1002/14651858.cd004370.pub2

Cited by 62 publications

(42 citation statements)

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“…We used steroids and immunoglobulin to treat the myocarditis. While immunoglobulin use has been reported to have no effect on mortality (19,20), a recent randomized study (21) suggested that steroid therapy significantly improves cardiac function in patients with viral myocarditis. It is difficult to determine the efficacy of steroid therapy for Legionellaassociated myocarditis because there are other confounding factors besides steroid therapy; however, it might provide some beneficial impact on the prognosis.…”

Section: Discussionmentioning

confidence: 99%

Severe Legionnaires' Disease with Pneumonia and Biopsy-Confirmed Myocarditis Most Likely Caused by <i>Legionella pneumophila</i> Serogroup 6

et al. 2012

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We herein describe the successful treatment of a patient with possible Legionella pneumophila serogroup 6 infection complicated by pneumonia and myocarditis. A 32-year-old man presented with a five-day history of cough, dyspnea and chest pain. Chest radiography revealed patchy opacities in both lungs suggestive of bilateral pneumonia, and a urinary antigen test for Legionella pneumophila was positive. After admission, the patient developed congestive heart failure due to pathologically confirmed myocarditis. He was successfully treated with minocycline, macrolide, steroids and noninvasive positive-pressure ventilation (NPPV). He eventually recovered with a normalized cardiac function. L. pneumophila serogroup 6 was isolated from the bathwater in the patient's home.

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Section: Discussionmentioning

confidence: 99%

Severe Legionnaires' Disease with Pneumonia and Biopsy-Confirmed Myocarditis Most Likely Caused by <i>Legionella pneumophila</i> Serogroup 6

et al. 2012

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“…16 A Cochrane review concluded that IVIG should not been given routinely in any cases of pediatric or adult patients with presumed viral myocarditis. 17 Likewise, the effectiveness of steroids in children with myocarditis had not been confirmed. 18 There is insufficient evidence to support the routine use of immunosuppressive therapy in pediatric myocarditis, except for giant cell and eosinophilic myocarditis.…”

Section: Treatmentmentioning

confidence: 99%

Clinical Features of Acute and Fulminant Myocarditis in Children　– 2nd Nationwide Survey by Japanese Society of Pediatric Cardiology and Cardiac Surgery –

Matsuura

Ichida

Saji

et al. 2016

Circ J

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Background: The 1st nationwide survey by the Japanese Society of Pediatric Cardiology and Cardiac Surgery of acute or fulminant myocarditis (AMC/FMC) in children revealed that the survival rate of FMC was only 51.6%. The 2nd nationwide survey was performed to evaluate the recent outcomes of pediatric myocarditis. Methods and Results:Questionnaires regarding patients aged ≤18 years with AMC/FMC during the period from January 2006 to December 2011 were mailed. A total of 221 cases (age 6.5±5.3 years, 116 boys and 105 girls) were reported. There were 145 (65.6%) and 74 cases (33.5%) of AMC/FMC, respectively; the type of myocarditis was not reported in the remaining 2 cases (0.9%). Viruses were identified in 56 cases (25.3%), including coxsackie B in 9 and influenza A in 8. Histopathology by either endomyocardial biopsy or autopsy was obtained in 38 cases (19.2%). Intravenous immunoglobulin was effective in 49 (34.3%) of 143 cases. Steroid therapy was effective in 20 (32.8%) of 61 cases. Mechanical circulatory support was given in 54 cases (24.4%) and 94.2% of them were patients with FMC. The survival rates for the whole study population, acute myocarditis, and FMC were 75.6%, 91.0%, and 48.6%, respectively. Conclusions:The survival rate of children with myocarditis was almost identical to that of 10 years ago. (Circ J 2016; 80: 2362 -2368

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“…Further studies to investigate independent and possibly yet unknown or unidentified influences in suicide are necessary [47][48][49][50][51][52].…”

Section: Limitations Of This Study Include the Followingmentioning

confidence: 99%

Dual epidemics of deaths by heroin overdose and suicide

Salerian¹

2017

Clin Res Trials

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Intravenous immunoglobulin for presumed viral myocarditis in children and adults

Cited by 62 publications

References 32 publications

Severe Legionnaires' Disease with Pneumonia and Biopsy-Confirmed Myocarditis Most Likely Caused by <i>Legionella pneumophila</i> Serogroup 6

Severe Legionnaires' Disease with Pneumonia and Biopsy-Confirmed Myocarditis Most Likely Caused by <i>Legionella pneumophila</i> Serogroup 6

Clinical Features of Acute and Fulminant Myocarditis in Children　– 2nd Nationwide Survey by Japanese Society of Pediatric Cardiology and Cardiac Surgery –

Dual epidemics of deaths by heroin overdose and suicide

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Intravenous immunoglobulin for presumed viral myocarditis in children and adults

Cited by 62 publications

References 32 publications

Severe Legionnaires' Disease with Pneumonia and Biopsy-Confirmed Myocarditis Most Likely Caused by <i>Legionella pneumophila</i> Serogroup 6

Severe Legionnaires' Disease with Pneumonia and Biopsy-Confirmed Myocarditis Most Likely Caused by <i>Legionella pneumophila</i> Serogroup 6

Clinical Features of Acute and Fulminant Myocarditis in Children – 2nd Nationwide Survey by Japanese Society of Pediatric Cardiology and Cardiac Surgery –

Dual epidemics of deaths by heroin overdose and suicide

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Clinical Features of Acute and Fulminant Myocarditis in Children　– 2nd Nationwide Survey by Japanese Society of Pediatric Cardiology and Cardiac Surgery –