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This retrospective study reviews 49 patients-one year with opiate and one year post treatment discontinuation -treated at a private outpatient psychopharmacology center. This retrospective study reviews the health status of 398 patients with two distinct subgroups, 17 local and 32 out-of-town patients. Results revealed significant rise in fatalities after opiate discontinuation. The review results are consistent with increased risk of premature death following opiate discontinuation. It may also suggest possibly not fully understood opiate associated neuroprotective mechanism to prevent premature death for some vulnerable subgroups.Submit Manuscript | http://medcraveonline.com J Psychol Clin Psychiatry 2015, 2(4): 00083

This study offers evidence to suggest that both normalcy and psychiatric illness are sensitively dependent upon prefrontal cortex function. In general, the emergence of psychiatric symptoms coincide with diminished influence of prefrontal cortex function. The mediating influence of prefrontal cortex may be independent of molecular and regional brain dysfunctions contributory to psychiatric illness.