Intravenous Immunoglobulin Therapy in Primary Vasculitides

Lukan, Norbert

doi:10.5772/21534

Cited by 2 publications

(1 citation statement)

References 78 publications

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“…Our patient received a combination of antibiotics, anticoagulants, and anti-inflammatory medications including methyl-prednisolone and IVIG. IVIG has not been used extensively in cerebral vasculitis; however, IVIG was infused for its anti-inflammatory effect through the modulation of cytokine antagonists and cytokine production, as previously reported [20]. We cannot specify which treatment affected the progression of the disease and improved his clinical condition, nor can we exclude the possibility that the cause of the stroke improved naturally.…”

Section: Discussionmentioning

confidence: 99%

Extensive and Progressive Cerebral Infarction after Mycoplasma pneumoniae Infection

Choi

Jeong

Lee

et al. 2017

Korean J Crit Care Med

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Acute cerebral infarctions are rare in children, however they can occur as a complication of a Mycoplasma pneumoniae (MP) infection due to direct invasion, vasculitis, or a hypercoagulable state. We report on the case of a 5-year-old boy who had an extensive stroke in multiple cerebrovascular territories 10 days after the diagnosis of MP infection. Based on the suspicion that the cerebral infarction was associated with a macrolide-resistant MP infection, the patient was treated with levofloxacin, methyl-prednisolone, intravenous immunoglobulin, and enoxaparin. Despite this medical management, cerebral vascular narrowing progressed and a decompressive craniectomy became necessary for the patient’s survival. According to laboratory tests, brain magnetic resonance imaging, and clinical manifestations, the cerebral infarction in this case appeared to be due to the combined effects of hypercoagulability and cytokine-induced vascular inflammation.

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Section: Discussionmentioning

confidence: 99%