Intravenous iron is effective in treating the anaemia of rheumatoid arthritis and is not associated with flares of synovitis

Cimmino, M. A.; Parisi, Marco; Querci, Giorgia; Ghio, Riccardo; Accardo, S

doi:10.1007/bf02247854

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…An observed increase in Hb values after intravenous iron administration in RA patients with anemia was not found to be clinically relevant (Cimmino et al 1997). Moreover, in the present study there was no Hb increase in the control groups (with or without RA), in spite of the fact that 77% of patients in those groups received iron.…”

Section: Discussioncontrasting

confidence: 75%

Patients with and without rheumatoid arthritis benefit equally from preoperative epoetin-α treatment

et al. 2006

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Background Preoperative epoetin-α administration is said to have a limited effect in patients with chronic inflammatory diseases such as rheumatoid arthritis (RA), due to lower iron availability. We studied the effects of preoperative epoetin-α treatment in orthopedic surgery patients in a daily life setting in which iron supplementation was assured, and compared the effects in RA and non-RA patients.Methods In an open, naturalistic, randomized controlled trial, 695 orthopedic surgery patients with preoperative hemoglobin (Hb) values of 10-13 g/dL, either with RA (113) or without RA (582), received either preoperative epoetin-α treatment added to standard care, or standard care alone. Hb values and transfusions were evaluated from entry into the study until 4-6 weeks after surgery.Results Both in RA and non-RA patients, perioperative Hb values were significantly higher and transfusion requirements were significantly lower in epoetin-α treated patients than in control patients (p < 0.001). In RA patients, the outcomes regarding Hb values were not significantly or relevantly different from non-RA patients.Interpretation Just as with orthopedic patients in general, RA patients benefit from preoperative epoetin-α treatment in combination with iron supplementation. We postulate that iron supplementation during epoetin-α therapy in RA patients is important for optimal efficacy.

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Section: Discussioncontrasting

confidence: 75%

Patients with and without rheumatoid arthritis benefit equally from preoperative epoetin-α treatment

et al. 2006

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“…Cimmino et al conducted a retrospective data survey including 175 patients and concluded that flares of RA were not associated with intravenous iron sucrose infusion. Iron gluconate was associated with a few flares but the data not statistically significant [9]. Kaltwasser and colleagues administered recombinant human erythropoietin to 28 patients with RA and additionally IV iron sucrose to the 23 who developed functional iron deficiency, with no RA flares.…”

Section: Resultsmentioning

confidence: 99%

“…The authors instead recommended use of antirheumatic treatment and felt that iron administration was counterproductive if there was no evidence of iron deficiency. Cimmino (1997) Clin Rheum 175 Iron Sucrose and Iron Sodium Gluconate…”

Section: Resultsmentioning

confidence: 99%

The safety of modern intravenous iron infusions in patients with rheumatoid arthritis – a review of the literature

2020

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Objectives: To assess the evidence for the safety of intravenous iron infusions in patients with rheumatoid arthritis. Methods: A systematic literature search was performed in June 2019 on PubMed and Cochrane databases for eligible studies. Results: There is significant evidence of safety and efficacy of intravenous iron in patients with rheumatoid arthritis using newer, less immunogenic iron preparations, such as iron sucrose and low molecular weight iron dextran preparations. Discussion: Iron deficiency anaemia has a significant impact on the quality of life of patients with rheumatoid arthritis, but the use of intravenous iron is generally avoided due to concerns raisedin older studies using high molecular weight iron dextran of exacerbating the disease. However, such concerns have not been confirmed in more recent studies using newer preparations. Conclusion: We find significant evidence of safety and efficacy in more recent studies of larger cohorts of patients using newer, less immunogenic iron preparations.

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Präoperative Anämie beim Rheumatiker

2022

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Intravenous iron is effective in treating the anaemia of rheumatoid arthritis and is not associated with flares of synovitis

Cited by 7 publications

References 5 publications

Patients with and without rheumatoid arthritis benefit equally from preoperative epoetin-α treatment

Patients with and without rheumatoid arthritis benefit equally from preoperative epoetin-α treatment

The safety of modern intravenous iron infusions in patients with rheumatoid arthritis – a review of the literature

Präoperative Anämie beim Rheumatiker

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