Intravesical Oxybutynin Hydrochloride in the Treatment of Urge Incontinence in the Elderly

Abstract

It is suggested that intravesical oxybutynin hydrochloride is an effective option of therapy for intractable urge incontinence in elderly people, however, the immediate posttreatment cystometrogram was not predictive of the response to intravesical therapy on overactive bladder in the elderly.

Treatment of overactive bladder with modified intravesical oxybutynin chloride

“…Brendler et al [1989] first reported the treatment of intravesical oxybutynin chloride for neurogenic bladder. Mizunaga et al [1996] reported intravesical oxybutynin with HPC for six healthy volunteers and seven overactive bladder patients. The mechanisms of action of intravesical oxybutynin, still unknown, may be the direct effect on the bladder muscle, topical anesthetic effect, and the indirect effect of absorbed oxybutynin and its metabolites.…”

“…There is, however, a subset patients who do not respond to oral medication or who experience intolerable systemic side effects from these drugs [Massada et al, 1992;Mizunaga et al, 1996;Buyse et al, 1998]. There is, however, a subset patients who do not respond to oral medication or who experience intolerable systemic side effects from these drugs [Massada et al, 1992;Mizunaga et al, 1996;Buyse et al, 1998].…”

“…These systemic side effects are reported to be caused by the high plasma level of its active metabolite N-desethyloxybutynin (DEOB) [Massada et al, 1992;Buyse et al, 1998]. Recently, to improve this deficiency, the use of oxybutynin chloride solution containing hydroxypropylcellulose (HPC), a mucosal adhesion substance, was reported (modified intravesical oxybutynin) [Mizunaga et al, 1996;Chiba et al, 1997]. However, the effect of intravesical oxybutynin chloride often does not last long enough.…”

Intravesical Oxybutynin for Neurogenic Bladder in Children

“…They reported that plasma concentrations of oxybutynin after intravesical HPC-modified oxybutynin were significantly lower than that after instillation of oxybutynin alone, and the effect of HPC-modified oxybutynin lasted longer than oxybutynin alone. Moreover, favorable clinical effects were achieved, and no AEs were observed for more than six months during medication periods [40]. In our first report on modified intravesical oxybutynin chloride in adult patients [41], six patients were treated with modified intravesical oxybutynin chloride.…”