Intravitreal bevacizumab for iatrogenic choroidal neovascular membrane following vitreoretinal surgery for retinal detachment

Abstract

We report the successful use of intravitreal bevacizumab in the iatrogenic choroidal neovascular membrane (CNVM) following vitreoretinal surgery. A 69-year-old male underwent vitrectomy surgery with silicone oil (SO) tamponade for rhegmatogenous retinal detachment. During fluid air exchange, there was an accidental retinal touch at an area in the papillomacular bundle with the silicone tip cannula. He had persistent subretinal bleed at the area 1 month after surgery. The optical coherence tomography (OCT) showed a subretinal elevated lesion and fluorescein angiography (FFA) showed an active CNVM. The patient was treated with intravitreal bevacizumab in the SO-filled eye. At 1-month postinjection, the OCT revealed reduction in the size of CNVM. The patient underwent SO removal with the second dose of intravitreal bevacizumab. CNVM regressed with no recurrence on follow-up at 1 year. Iatrogenic CNVM is a rare complication following successful vitreoretinal surgery. Prompt diagnosis and treatment with intravitreal bevacizumab may be required for a favorable outcome.

A case of recurrent viral retinitis treated with intravitreal antiviral agents in a silicone oil filled eye

“…Efficacy of anti-VEGF antibody preparations and corticosteroids have been described without retinal toxicity. [17][18][19] Animal studies have shown safety with findings supporting clinical practice of using unadjusted dosage of intravitreal antiviral injection and implant. Ganciclovir dosages of up to 200 mcg/0.1 mL were safe for serial intravitreal injection in rabbit eyes filled with silicone oil.…”

“…Efficacy of anti-VEGF antibody preparations and corticosteroids have been described without retinal toxicity. 17–19…”

Bevacizumab for Post Vitrectomy Cystoid Macular Edema in a Silicone Oil–filled Eye

“…growth factor therapy in a silicone oil-filled eye was found to be safe and effective for iris neovascularisation, neovascular glaucoma, myopic choroidal neovascular membrane, and choroidal neovascularization after vitrectomy. [6][7][8][9] In a meta-analysis, a dexamethasone implant was known to increase the anatomical outcomes significantly in patients of diabetic macular edema but was not known to improve the visual acuity, especially in phakic patients due to development of cataract. 10 There has been a case report of the use of dexamethasone implant for recurrent macular edema in a silicone oil-filled eye.…”

Identification of Key Contributive Compounds in a Herbal Medicine: A Novel Mathematic—Biological Evaluation Approach

“…Around 3.2 million people worldwide are suffering from DR [7] . However, conventional anti‐DR therapies, including laser photocoagulation and vitrectomy surgery, are unsatisfactory due to the unavoidable side‐effects [8] . Notably, medicinal herbal treatment exerted positive effects on alleviating DR‐induced complications [9] .…”