Intravitreal bromfenac liposomal suspension (100 μg / 0.1 ml). A safety study in rabbit eyes

Sanchez-Santos, Idaira; García-Sánchez, Gustavo Adolfo; González-Salinas, Roberto; Linares-Alba, Mónica Anayatzin; Rodríguez-Reyes, Abelardo; García-Santisteban, Rodrigo; Tirado-Gonzalez, Vanessa; Hernández-Piñamora, Elsa; García-Arzate, Daniel; Morales-Cantón, Virgilio; Quiroz‐Mercado, Hugo

doi:10.1016/j.exer.2020.108020

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…В токсикологических исследованиях метод ЭФИ является предпочтительным за счет того, что электрофизиологические изменения наблюдаются задолго до гистологических изменений, по которым также производится функциональная оценка состояния сетчатки. С помощью различных методов ЭФИ зрительный анализатор можно разделить на участки от наружной сетчатки до зрительной коры, что помогает в токсикологических исследованиях определить, как вещество влияет на сетчатку, оценить точку приложения лекарственных препаратов как при системном, так и при локальном применении, например при интравитреальных введениях [20]. Так, электроретинограмма (ЭРГ) позволяет оценить состояние первых двух слоев сетчатки [17].…”

Section: оценка ретинотоксичности на базе электрофизиологических сигн...unclassified

Ophthalmic Bioengineering. Review

et al. 2023

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This article published the materials of the round table “Bioengineering in ophthalmology” (OphthalmicBioengineering), held on May 13, 2021 as part of the international conference Ural Symposium on Biomedical Engineering, Radioelectronics and Information Technology (USBEREIT). USBEREIT is held under the auspices of the IEEE Engineering in Medicine and Biology Society. The article presents reports on: metrological aspects of registration of tonometric and electrophysiological signals in ophthalmic diagnostics; approaches to modeling the processes of pulse blood filling of the eye with the determination of hemodynamic parameters; retinotoxicity based on electrophysiological signals; analysis of electrophysiological signals in the frequency-time domain and its application in clinical practice; extraction and analysis of specialized data obtained from the electrophysiological medical device; as well as diagnosing retinal diseases based on optical coherence tomography using machine learning.

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Section: оценка ретинотоксичности на базе электрофизиологических сигн...unclassified

Ophthalmic Bioengineering. Review

et al. 2023

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“…Corticosteroids and particularly dexamethasone have been investigated, especially in combined therapies for their potent anti-inflammatory effects as well as their ability to stabilize the blood-retinal barrier and reduce exudative processes [16]. Furthermore, some non-steroidal anti-inflammatory drugs (NSAID), such as ketorolac or bromfenac, have been also used alone [17] or in combination with anti-VEGF therapies, in order to reduce retinal thickness caused by macular edema, counteract the inflammation processes in degenerative processes and avoid the inflammation caused by the intravitreal injection itself [18]. D-alpha-tocopherol polyethylene glycol succinate (TPGS) has been included in various drug delivery systems to enhance bioavailability and drug efficacy [19].…”

Section: Introductionmentioning

confidence: 99%

Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases

et al. 2021

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The present study aims to develop a thermo-responsive-injectable hydrogel (HyG) based on PLGA-PEG-PLGA (PLGA = poly-(DL-lactic acid co-glycolic acid); PEG = polyethylene glycol) to deliver neuroprotective agents to the retina over time. Two PLGA-PEG PLGA copolymers with different PEG:LA:GA ratios (1:1.54:23.1 and 1:2.25:22.5) for HyG-1 and HyG-2 development respectively were synthetized and characterized by different techniques (gel permeation chromatography (GPC), nuclear magnetic resonance (NMR), dynamic light scattering (DLS), critical micelle concentration (CMC), gelation and rheological behaviour). According to the physicochemical characterization, HyG-1 was selected for further studies and loaded with anti-inflammatory drugs: dexamethasone (0.2%), and ketorolac (0.5%), alone or in combination with the antioxidants idebenone (1 µM) and D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) (0.002%). In vitro drug release and cytotoxicity studies were performed for the active substances and hydrogels (loaded and drug-free). A cellular model based on oxidative stress was optimized for anti-inflammatory and antioxidant screening of the formulations by using retinal-pigmented epithelial cell line hTERT (RPE-1). The copolymer 1, used to prepare thermo-responsive HyG-1, showed low polydispersity (PDI = 1.22) and a strong gel behaviour at 25% (w/v) in an isotonic buffer solution close to the vitreous temperature (31–34 °C). Sustained release of dexamethasone and ketorolac was achieved between 47 and 62 days, depending on the composition. HyG-1 was well tolerated (84.5 ± 3.2%) in retinal cells, with values near 100% when the anti-inflammatory and antioxidant agents were included. The combination of idebenone and dexamethasone promoted high oxidative protection in the cells exposed to H2O2, with viability values of 86.2 ± 14.7%. Ketorolac and dexamethasone-based formulations ameliorated the production of TNF-α, showing significant results (p ≤ 0.0001). The hydrogels developed in the present study entail a novel biodegradable tool to treat neurodegenerative processes of the retina overtime.

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Recent updates on drug delivery approaches for improved ocular delivery with an insight into nanostructured drug delivery carriers for anterior and posterior segment disorders

Khan,

Do,

2024

Drug Deliv. and Transl. Res.

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Intravitreal bromfenac liposomal suspension (100 μg / 0.1 ml). A safety study in rabbit eyes

Cited by 6 publications

References 23 publications

Ophthalmic Bioengineering. Review

Ophthalmic Bioengineering. Review

Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases

Recent updates on drug delivery approaches for improved ocular delivery with an insight into nanostructured drug delivery carriers for anterior and posterior segment disorders

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