Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases

López-Cano, José Javier; Sigen, A; Andrés‐Guerrero, Vanessa; Tai, Hongyun; Bravo‐Osuna, Irene; Molina‐Martínez, Irene T.; Wang, Wenxian; Herrero–Vanrell, R.

doi:10.3390/pharmaceutics13020234

Cited by 32 publications

(25 citation statements)

References 61 publications

(87 reference statements)

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“…7 of Lopez-cano et al's paper are modeled using this method and force field. This article, which is an MDPI article 38 , deals with the treatment of retinal degenerative diseases with the help of PLGA-PEG-PLGA hydrogel. In Fig.…”

Section: Methodsmentioning

confidence: 99%

Biomolecular engineering of drugs loading in Riboflavin-targeted polymeric devices: simulation and experimental

Khedri

Moraveji

2022

Sci Rep

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The synthesis of polymeric nanoparticles (NPs) with efficient drug loading content and targeting moieties is an attractive field and remains a challenge in drug delivery systems. Atomistic investigations can provide an in-depth understanding of delivery devices and reduce the number of expensive experiments. In this paper, we studied the self-assembly of poly (lactic-co-glycolic acid)-b-poly (ethylene glycol) with different molecular weights and surface compositions. The innovation of this molecular study is the loading of an antitumor drug (docetaxel) on a targeting ligand (riboflavin). According to this work, a novel, biocompatible and targeted system for cancer treatment has been developed. The obtained results revealed a correlation between polymer molecular weight and the stability of particles. In this line, samples including 20 and 10 w/w% moiety NPs formed from polymers with 3 and 4.5 kDa backbone sizes, respectively, are the stable models with the highest drug loading and entrapment efficiencies. Next, we evaluated NP morphology and found that NPs have a core/shell structure consisting of a hydrophobic core with a shell of poly (ethylene glycol) and riboflavin. Interestingly, morphology assessments confirmed that the targeting moiety located on the surface can improve drug delivery to receptors and cancerous cells. The developed models provided significant insight into the structure and morphology of NPs before the synthesis and further analysis of NPs in biological environments. However, in the best cases of this system, Dynamic Light Scattering (DLS) tests were also taken and the results were consistent with the results obtained from All Atom and Coarse Grained simulations.

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Section: Methodsmentioning

confidence: 99%

Biomolecular engineering of drugs loading in Riboflavin-targeted polymeric devices: simulation and experimental

Khedri

Moraveji

2022

Sci Rep

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“…The method is simple and the raw materials are easily available. The particle size of the microspheres and the drug loading rate showed good results (21). Studies showed that the stronger the drug was when the nanoparticle size was at the level of 50-100nm (22)(23).…”

Section: Comparison Of Clinical Effectsmentioning

confidence: 99%

The Impact of Dexmedetomidine-loaded Nano-microsphere Combined with Percutaneous Acupoint Electrical Stimulation on the Postoperative Cognitive Function of Elderly Patients with Hip Fracture

Wang¹,

Wang²,

Yang³

2022

Cell Mol Biol (Noisy-le-grand)

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To explore the impact of nano-microsphere loaded with dexmedetomidine (DEX) combined with percutaneous acupoint electrical stimulation on the postoperative cognitive function of elderly patients with hip fracture. The free base was prepared by the alkali precipitation method in this research, and then the drug was loaded into PLGA microspheres to construct the drug sustained-release system. The PLAG microspheres loaded with DEX (MS/DEX) were prepared by the O/W emulsion volatilization method and then Gel-(DEX-MS/BUP) suspension was obtained. A scanning electron microscope (SEM) was used to analyze the characterization of the prepared drug-loaded nano-microsphere, rheological analysis was performed on the copolymer solution, and in vivo release and degradation, experiments were carried out. Wistar rats were randomly divided into four groups (n=ten). After the sciatic nerve block model was established, the block time was observed after the injection of each sustained-release agent. The results showed that the gel-forming temperature of Gel and Gel-(DEX-MS/BUP) were 27.3°C and 26.3°C, respectively. Both MS/BUP and Gel-(DEX-MS/BUP) drugs could completely enter the blocking state. There was no loss of motor function in the rats after GEL-DEX. The clinical trials showed that Gel-(DEX-MS/BUP) system had good in situ and sustained release effects, and the analgesic effect of local anesthesia was significantly improved.

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“…Combining PLGA-PEG-PLGA to Avastin ® shifted sol-gel transition to low temperature. These are used for treating posterior segment disease of the eyes [ 270 , 271 ].…”

Section: Patent and Current Clinical Trial Status Of The Hydrogel Dru...mentioning

confidence: 99%

Functional Thermoresponsive Hydrogel Molecule to Material Design for Biomedical Applications

et al. 2022

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Temperature-induced, rapid changes in the viscosity and reproducible 3-D structure formation makes thermos-sensitive hydrogels an ideal delivery system to act as a cell scaffold or a drug reservoir. Moreover, the hydrogels’ minimum invasiveness, high biocompatibility, and facile elimination from the body have gathered a lot of attention from researchers. This review article attempts to present a complete picture of the exhaustive arena, including the synthesis, mechanism, and biomedical applications of thermosensitive hydrogels. A special section on intellectual property and marketed products tries to shed some light on the commercial potential of thermosensitive hydrogels.

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Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases

Cited by 32 publications

References 61 publications

Biomolecular engineering of drugs loading in Riboflavin-targeted polymeric devices: simulation and experimental

Biomolecular engineering of drugs loading in Riboflavin-targeted polymeric devices: simulation and experimental

The Impact of Dexmedetomidine-loaded Nano-microsphere Combined with Percutaneous Acupoint Electrical Stimulation on the Postoperative Cognitive Function of Elderly Patients with Hip Fracture

Functional Thermoresponsive Hydrogel Molecule to Material Design for Biomedical Applications

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