Intravitreal ranibizumab injection at the end of vitrectomy for diabetic vitreous hemorrhage (Observational Study)

Xu, Liang; Zhang, Yue; Wang, Jiaxing; Wang, Lifei; Huang, Wan‐Rong; Tang, Xin

doi:10.1097/md.0000000000015735

Cited by 8 publications

(11 citation statements)

References 36 publications

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“…The current treatment for wet AMD includes use of anti-VEGF monoclonal antibodies such as ranibizumab and aflibercept [ 6 ]. Although highly effective, each intravitreal injection has the risk of adverse ocular events like endophthalmitis, retinal detachment and retinal hemorrhage [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Self-Assembling Tacrolimus Nanomicelles for Retinal Drug Delivery

et al. 2020

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Neovascular age-related macular degeneration (AMD) is characterized by an increase in reactive oxygen species (ROS) and pro-inflammatory cytokines in the retinal pigment epithelium cells. The primary purpose of this study was the development of a clear, tacrolimus nanomicellar formulation (TAC-NMF) for AMD. The optimized formulation had a mean diameter of 15.41 nm, a zeta potential of 0.5 mV, and an entrapment efficiency of 97.13%. In-vitro cytotoxicity studies revealed the dose-dependent cytotoxicity of TAC-NMF on various ocular cell lines, such as human retinal pigment epithelium (D407), monkey retinal choroidal endothelial (RF/6A) cells, and human corneal epithelium (CCL 20.2) cells. Cellular uptake and in-vitro distribution studies using flow cytometry and confocal microscopy, respectively, indicated an elevated uptake of TAC-NMF in a time-dependent manner. Biocompatibility assay using macrophage RAW 264.7 cell line resulted in low production of inflammatory cytokines such as IL-6, IL-1β and TNF-α after treatment with TAC-NMF. There was a decrease in ROS in D407 cells pre-treated with sodium iodate (ROS inducing agent) after treating with TAC-NMF and tacrolimus drug. Similarly, there was a reduction in the pro-inflammatory cytokines and VEGF-A in D407 cells pretreated with sodium iodate. This indicates that TAC-NMF could lower pro-inflammatory cytokines and ROS commonly seen in AMD.

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Section: Introductionmentioning

confidence: 99%

Self-Assembling Tacrolimus Nanomicelles for Retinal Drug Delivery

et al. 2020

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“…Wakabayashi et al detected that vitreous VEGF levels during vitrectomy were significantly higher in eyes with early VH and NVG than in those without [38]. Moreover, intravitreal anti-VEGF therapy before or at the end of vitrectomy is considered to prevent post-vitrectomy complications [41,42]. In this retrospective study, we could not measure the vitreous VEGF concentrations during vitrectomy.…”

Section: Discussionmentioning

confidence: 78%

“…Regarding ophthalmic predictors influencing postoperative complications after vitrectomy in patients with diabetes and PDR, numerous recent studies have focused on the relationship between the vitreous level of VEGF and post-surgical outcomes [38][39][40][41][42]. Wakabayashi et al detected that vitreous VEGF levels during vitrectomy were significantly higher in eyes with early VH and NVG than in those without [38].…”

Section: Discussionmentioning

confidence: 99%

Is Chronic Kidney Disease Affecting the Postoperative Complications of Vitrectomy for Proliferative Diabetic Retinopathy?

Kameda

Saeki

Hanai

et al. 2021

JCM

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Chronic kidney disease (CKD) is a well-known risk factor for postoperative complications in several surgical fields. However, although prevalent among diabetic candidates for vitrectomy, the effect of CKD on vitrectomy outcomes remains unclear. This study aimed at clarifying the relationship between CKD and the occurrence of vitrectomy-related complications in patients with proliferative diabetic retinopathy (PDR). The 6-month incidences of vitreous hemorrhage (VH) and neovascular glaucoma (NVG) following vitrectomy for PDR were compared among the following groups: stages 1–2 CKD (60 patients), stages 3–5 CKD (70 patients not on hemodialysis), and hemodialysis (HD; 30 patients). We also determined whether the deterioration of the estimated glomerular filtration rate (eGFR) was associated with post-vitrectomy events. The incidence of VH was significantly higher in the stages 3–5 CKD group (43%) than in the stages 1–2 CKD (10%) and HD (10%) groups. NVG was more common in the stages 3–5 CKD group (17%) than in the stages 1–2 CKD (2%) and HD (0%) groups. The reduced estimated glomerular filtration rate (eGFR) was the only significant variable associated with post-vitrectomy VH and NVG. Patients with PDR and CKD, particularly those with lower eGFR, might be at risk for post-vitrectomy VH and NVG.

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“…Sato et al reported incidences of early and late post-vitrectomy VH were 18.9 and 17.9%, respectively [ 12 ]. And the occurrence of early recurrent VH in another study was 24.3% without injection of ranibizumab [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Characteristics and outcomes of vitrectomy for proliferative diabetic retinopathy in young versus senior patients

et al. 2020

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Background Proliferative diabetic retinopathy (PDR) is one of the most common cause of vision loss in diabetic patients, and the incidence age of PDR patients gradually gets younger. This study aims to compare the characteristics of PDR and outcomes following vitrectomy in young and senior patients. Methods This is a retrospective case series study. Data of 116 eyes of 92 patients who underwent vitrectomy for PDR from February 2012 to February 2017 were reviewed, which were divided into young and senior patient groups. All patients were followed up for 24 months at least. Results There were 62.1% of eyes with tractional retinal detachment secondary to PDR in the young patient group, while only 12.1% of eyes in the senior patient group with this surgery indication. (P < 0.001) The best corrected visual acuity increased in 41 eyes (70.7%), stable in 9 eyes (15.5%), and decreased in 8 eyes (13.8%) in young patients at the final follow-up. And it increased in 47 eyes (81.0%), stable in 2 eyes (3.4%), and decreased in 9 eyes (15.5%) in senior patients.(P = 0.085) Postoperative complications mainly included recurrent vitreous hemorrhage (24.1%), retinal detachment (3.4%), neovascular glaucoma (NVG) (27.6%) and nuclear sclerosis (53.4%) in young patients, and it was 19.0, 0.0, 1.7 and 3.4% in senior patients respectively. Conclusion PDR of young patients is more severe than that of senior patients, and vitrectomy is an effective and safe method for PDR treatment. NVG is a main and severe complication besides nuclear sclerosis in young patients, and the incidence of NVG is higher compared to that in senior patients.

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Intravitreal ranibizumab injection at the end of vitrectomy for diabetic vitreous hemorrhage (Observational Study)

Cited by 8 publications

References 36 publications

Self-Assembling Tacrolimus Nanomicelles for Retinal Drug Delivery

Self-Assembling Tacrolimus Nanomicelles for Retinal Drug Delivery

Is Chronic Kidney Disease Affecting the Postoperative Complications of Vitrectomy for Proliferative Diabetic Retinopathy?

Characteristics and outcomes of vitrectomy for proliferative diabetic retinopathy in young versus senior patients

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