Intravitreal Toxicity of Hydroxyacyclovir (BW-B759U), a New Antiviral Agent

Pulido, Jose; Peyman, Gholam A.; Lesar, Timothy S.; Vernot, Jackie

doi:10.1001/archopht.1985.01050060100036

Cited by 40 publications

(3 citation statements)

References 7 publications

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“…Hasel L l \ 0030-3755/96/2104 0215 SIO.00/0 li-Mail kargem« kargcr.ch l ax +4! 61 306 12 34 hup: /www.kargcr.ch the drug [5][6][7]. To date, numerous works have appeared in respect of this field of research [8][9][10].…”

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confidence: 47%

Intravitreal Application of Ganciclovir in Rabbits: ERG and Electron-Microscopic Findings

et al. 1996

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The retinal toxic effect after intravitreal use of ganciclovir has been the subject of our experimental investigation on 20 New Zealand rabbits. Different doses of ganciclovir ranging from 200 to 600 µg/0.1 ml were injected intravitreously, and ERG changes were recorded at different time points after drug administration. Finally the animals were killed and the retinal lesions were studied by electron microscopy. According to our experiments, ganciclovir doses of 300-600 µg/0.1 ml have a clearly toxic effect on the retina as shown by ERG changes. One month after the injection, the electroretinogram is either extinguished or clearly affected. Noteworthy is the fact that in a dose of 200 µg/0.1 ml, the ERG b-wave shows a 20% reduction of its normal amplitude 4 months after ganciclovir delivery. Electron microscopy of the retina revealed in the inner segment of the receptor cells the existence of dilatation and vesiculation of the endoplasmic reticulum in the surrounding nuclear cytoplasm and swelling of the mitochondria with fragmentation of the cristae in several of them. In the outer segment of the photoreceptor cells, degeneration and destruction of the lamellae accompagnied by disintegration of the adjacent protoplasm in parts of certain rods and cones appeared. Finally large vacuoles of irregular shape in the synapses and degenerative mitochondria and empty vacuoles in the optic nerve fibers were shown.

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confidence: 47%

Intravitreal Application of Ganciclovir in Rabbits: ERG and Electron-Microscopic Findings

et al. 1996

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“…Pulido investigated the retina toxicity of GCV intravitreal injection in the rabbit. Intravitreal doses of 400 μ g produced no discernible ophthalmoscopic or histologic changes and no changes in electroretinography B-waves [24]. Peyman also demonstrated no evidence of retinal toxicity by clinical or light microscopic examination at different time intervals up to 14 days after intravitreal injections of liposome-encapsulated GCV (94 µ g/0.1 mL) and trifluridine (102 µ g/0.1 mL) [25].…”

Section: Discussionmentioning

confidence: 99%

Retinal and Corneal Toxicity and Pharmacokinetic Analysis of Intraocular Injection of Ganciclovir in Rabbit Eyes

Sun

Peng

Lü

et al. 2019

Journal of Ophthalmology

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Purpose. To evaluate the safety and pharmacokinetic changes of ganciclovir (GCV) intraocular injection. Methods. GCV (2 mg/0.1 mL) was injected into rabbit eyes. Aqueous GCV concentration was detected by high-performance liquid chromatography. Potential toxicity was assessed by slit-lamp examination, optical coherence tomography, fundus examination, confocal microscopy, and histology. Results. Aqueous GCV concentrations were 24.83 ± 6.41 μg/mL, 0.65 ± 0.52 μg/mL, and undetected on the 1st, 3rd, and 7th day after intravitreal injection. GCV could not be detected on the first day after intracameral injection. No corneal abnormality was found after intravitreal injection, but retinal edema was observed on the first day which receded later. Corneal edema was obvious with endothelial cytoarchitecture damaged after intracameral injection; fluid retention also existed in retina. Conclusions. GCV intravitreal injection offers effective, sustained drug concentration in the anterior chamber, and its damage to retina receded over time. Intracameral injection results in rapid drug elimination and severe damage to endothelium and thus is not recommended.

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“…Τα αποτελέσματα αυτά βρίσκονται σε αντίθεση με τις εργασίες των Pulliado 362 , Payman 354_362 Κ αι άλλων, που θεωρούν ότι η δόση των 200 pg/0.1 ml είναι ατοξική για τον αμφιβληστροειδή. Ακόμη περισσότερο θέτει ορισμένα ερωτήματα για την αθωότητα της ενδουαλοειδικής έγχυσης του φαρμάκου.…”

Section: ομαδα 3ηunclassified

Διαταραχες Του Ηλεκτροαμφιβληστροειδογραφηματος Και Ιστολογικη Μελετη Του Αμφιβληστροειδους Με Το Ηλεκτρονικο Μικροσκοπιο Μετα Ενδουαλοειδικη Εγχυση Του Ganciclovir Σε Πειραματοζωα

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Intravitreal Toxicity of Hydroxyacyclovir (BW-B759U), a New Antiviral Agent

Cited by 40 publications

References 7 publications

Intravitreal Application of Ganciclovir in Rabbits: ERG and Electron-Microscopic Findings

Intravitreal Application of Ganciclovir in Rabbits: ERG and Electron-Microscopic Findings

Retinal and Corneal Toxicity and Pharmacokinetic Analysis of Intraocular Injection of Ganciclovir in Rabbit Eyes

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