Intrinsic neuronal control of the pyloric sphincter of the lamb

Mazzuoli, Gemma; Lucherini, Mark; Russo, Domenico; Clavenzani, Paolo; Chiocchetti, Roberto

doi:10.1016/j.jchemneu.2008.05.002

Cited by 12 publications

(13 citation statements)

References 43 publications

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“…Similarly, large number of adrenergic nerve structures were observed in the region of the pyloric sphincter in rat (Gillespie and Maxwell, 1971), guinea pig (Costa and Gabella, 1968), dog (Allescher et al, 1989a) and sheep (Mazzuoli et al, 2008). Functionally, adrenergic innervation mostly acts as an inhibitor of the pyloric contraction, but the opposite influence was additionally noticed.…”

Section: Adrenergic and Dopaminergic Innervationmentioning

confidence: 94%

“…Despite years of studies on the pyloric innervation, hitherto data are incomplete and concern such animals as guinea pig (Elfvin and Lindh, 1982), rat (Hayakawa et al, 2007;Lindestrom and Ekblad, 2002) and sheep (Cottrell and Greenhorn, 1987;Mazzuoli et al, 2008). Previous experiments on the innervation of the swine gastrointestinal tract have focused mainly on the extrinsic innervation of the small intestine (Kaleczyc et al, 2004;Pidsudko et al, 2011), large intestine (Pidsudko et al, 2001;Skobowiat et al, 2010aSkobowiat et al, ,b, 2011 and the intrinsic innervation of the different parts of the digestive tract (Barbiers et al, 1993b;Kaleczyc et al, 2007;Melander et al, 1985;Porcher et al, 2000;Scheuermann and Stach, 1984;Timmermans et al, 1990;Van Ginneken et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

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Localization and neurochemical characteristics of the extrinsic sympathetic neurons projecting to the pylorus in the domestic pig

Załęcki

2012

Journal of Chemical Neuroanatomy

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Section: Adrenergic and Dopaminergic Innervationmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Localization and neurochemical characteristics of the extrinsic sympathetic neurons projecting to the pylorus in the domestic pig

Załęcki

2012

Journal of Chemical Neuroanatomy

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“…Studies have shown that slow gastric emptying with a high‐fat test meal was associated with decreased antral and increased duodenal contractile activity . Moreover, duodenal contractions may cause closure of the pyloric sphincter that in turn corresponds with the isolated pyloric pressure waves (IPPW) on intraluminal manometry …”

Section: Gastric Emptying During the Digestive Periodmentioning

confidence: 99%

Advances in the physiology of gastric emptying

Goyal

Guo

Mashimo

2019

Neurogastroenterology Motil

236

154

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There have been many recent advances in the understanding of various aspects of the physiology of gastric motility and gastric emptying. Earlier studies had discovered the remarkable ability of the stomach to regulate the timing and rate of emptying of ingested food constituents and the underlying motor activity. Recent studies have shown that two parallel neural circuits, the gastric inhibitory vagal motor circuit (GIVMC) and the gastric excitatory vagal motor circuit (GEVMC), mediate gastric inhibition and excitation and therefore the rate of gastric emptying. The GIVMC includes preganglionic cholinergic neurons in the DMV and the postganglionic inhibitory neurons in the myenteric plexus that act by releasing nitric oxide, ATP, and peptide VIP. The GEVMC includes distinct gastric excitatory preganglionic cholinergic neurons in the DMV and postganglionic excitatory cholinergic neurons in the myenteric plexus. Smooth muscle is the final target of these circuits. The role of the intramuscular interstitial cells of Cajal in neuromuscular transmission remains debatable. The two motor circuits are differentially regulated by different sets of neurons in the NTS and vagal afferents. In the digestive period, many hormones including cholecystokinin and GLP‐1 inhibit gastric emptying via the GIVMC, and in the inter‐digestive period, hormones ghrelin and motilin hasten gastric emptying by stimulating the GEVMC. The GIVMC and GEVMC are also connected to anorexigenic and orexigenic neural pathways, respectively. Identification of the control circuits of gastric emptying may provide better delineation of the pathophysiology of abnormal gastric emptying and its relationship to satiety signals and food intake.

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“…The study involving the experimental denervation of the rat pylorus provided similar data (Lindestrom and Ekblad 2002). On the other hand, investigations performed in lambs have revealed the presence of as many as 61% of SP-immunoreactive intramural descending neurons innervating the pyloric sphincter (Mazzuoli et al 2008). Since the present experiment and the study of Mazzuoli et al (2008) were carried out with the same neuronal tracer (Fast Blue), the discrepancies observed probably result from interspecies differences.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, investigations performed in lambs have revealed the presence of as many as 61% of SP-immunoreactive intramural descending neurons innervating the pyloric sphincter (Mazzuoli et al 2008). Since the present experiment and the study of Mazzuoli et al (2008) were carried out with the same neuronal tracer (Fast Blue), the discrepancies observed probably result from interspecies differences. Moreover, about 43% of the total abomasal myenteric neuronal population in the lamb were SP-immunoreactive, while in the control pigs about 13–15% of stomach corpus and antrum myenteric neurons stained for this peptide.…”

Section: Discussionmentioning

confidence: 99%

Gastric ulcer induced changes in substance P and Nk1, Nk2, Nk3 receptors expression in different stomach localizations with regard to intrinsic neuronal system

Załęcki

2018

Histochem Cell Biol

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Gastric ulceration, a focal tissue damage accompanied by inflammation, can influence other parts of the stomach. Substance P and its receptors are strongly involved in regulation of gastrointestinal motility, secretion and inflammation. The enteric nervous system is one of the regulators of gastrointestinal functioning and contributes to tissue response to the pathology. The pig, an omnivorous animal, is a valuable species for gastrointestinal experiments. Thus, the objective of the study was to verify whether the antral ulceration induces changes in the expression of substance P and tachykinin receptors in the neighboring (antrum) and distanced (corpus, pylorus) porcine gastric tissues and therein localized myenteric and submucosal perikarya as well as in the intrinsic descending neurons supplying pyloric sphincter. The experiment was performed on healthy pigs and pigs with experimentally induced gastric ulcers. Stomach samples from the corpus, antrum (adjacent to the ulcer in experimental pigs) and pylorus were analyzed by: (1) double immunofluorescence for changes in the number of SP-positive myenteric and submucosal neurons (2) Real-Time PCR for changes in expression of mRNA encoding SP and Nk1, Nk2, Nk3 receptors. Additionally, gastric descending neurons supplying pyloric sphincter were immunostained for SP. In experimental animals, only the number of SP-positive myenteric perikarya significantly increased in all stomach localizations studied. Q-PCR revealed increased expression for: SP, Nk1, Nk3 in the corpus; Nk2 and Nk3 in the pylorus; In the antrum, expression of Nk3 was increased but Nk2-decreased. Antral ulcers induced significant changes in the expression of SP and tachykinin receptors in the wide stomach area indicating sophisticated tissue reaction.

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Intrinsic neuronal control of the pyloric sphincter of the lamb

Cited by 12 publications

References 43 publications

Localization and neurochemical characteristics of the extrinsic sympathetic neurons projecting to the pylorus in the domestic pig

Localization and neurochemical characteristics of the extrinsic sympathetic neurons projecting to the pylorus in the domestic pig

Advances in the physiology of gastric emptying

Gastric ulcer induced changes in substance P and Nk1, Nk2, Nk3 receptors expression in different stomach localizations with regard to intrinsic neuronal system

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