Intrinsic Strain-Mediated Ultrathin Ceria Nanoantioxidant

Abstract

Metal oxide nanozymes have emerged as the most efficient and promising candidates to mimic antioxidant enzymes for treatment of oxidative stress-mediated pathophysiological disorders, but the current effectiveness is unsatisfactory due to insufficient catalytic performance. Here, we report for the first time an intrinsic strain-mediated ultrathin ceria nanoantioxidant. Surface strain in ceria with variable thicknesses and coordinatively unsaturated Ce sites was investigated by theoretical calculation analysis and then was validated by preparing ∼1.2 nm ultrathin nanoplates with ∼3.0% tensile strain in plane/∼10.0% tensile strain out of plane. Compared with nanocubes, surface strain in ultrathin nanoplates could enhance the covalency of the Ce−O bond, leading to increasing superoxide dismutase (SOD)-mimetic activity by ∼2.6-fold (1533 U/mg, in close proximity to that of natural SOD) and total antioxidant activity by ∼2.5-fold. As a proof of concept, intrinsic strain-mediated ultrathin ceria nanoplates could boost antioxidation for improved ischemic stroke treatment in vivo, significantly better than edaravone, a commonly used clinical drug.

Ultrasmall Cu2O@His Nanozymes with RONS Scavenging Capability for Anti-inflammatory Therapy

“…(B) SOD-like activity and Cu 2 O@His concentration relationships. (C) IC 50 comparison diagram of SOD-like activity nanozymes. ,− Size: MOF-818 (240 nm), CeVO 4 (15 nm), Mn 3 O 4 flowers (180 nm), Cu-Sazyme (∼300 nm), NiO nanoflowers (∼2.6 μm), Ceria nanocubes (6.44 nm ±0.42), Ultrathin ceria (50.09 ± 2.96 nm). (D) EPR spectra for O 2 •– scavenging ability of Cu 2 O@His.…”

Enhancing CO2 electroreduction performance through transition metal atom doping and strain engineering in γ-GeSe: a first-principles study

“…Numerous theoretical and experimental reports have highlighted the effects of strain on catalysts. 58–61 For instance, Fan et al reported enhanced catalytic performance in the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) of Pt-doped Ti 2 CX 2 (X = O and C) through strain engineering, attributed to d-band centers and work functions. 62,63 Compared to the α-phase and β-phase of GeSe, γ-GeSe exhibits in-plane isotropic elastic modulus characteristics.…”

Boundary‐Rich Carbon‐Based Electrocatalysts with Manganese(II)‐Coordinated Active Environment for Selective Synthesis of Hydrogen Peroxide

“…In addition, the enrichment of local concentration of reactants through wettability and/or micro/nanostructure modulation of electrocatalysts were found beneficial for boosting reaction kinetics. [21][22][23] While, the reactant enrich-ment effect for heterogeneous transition metal-coordinated electrocatalysts in 2e-ORR yet remains unclear.…”