Operational Transconductance Amplifier (OTA) designed with Omega-gate Nanowire SOI MOSFETs was evaluated. The transistor model was created using Verilog-A language and a Look-Up Table strategy, which is based on very precise measurements of the fabricated device. For the model, both the current and capacitance responses were considered. The proposed OTA showed a very good results with a voltage gain of 69.5 dB and a gain–bandwidth product (GBW) of 724 MHz. After that, a comparison among OTAs using different technologies was performed, showing that although the OTA designed with omega gate nanowire does not reach the same voltage gain of one designed with nanosheets, the proposed OTA shows a better GBW and smaller compensation capacitor for the same load capacitance. Considering the complexity of the nanosheet manufacture and the cost, the OTA designed with W-gate nanowire appears as a promising solution to replace FinFETs in the future.