This paper aims to explore the potential of political cartoon discourse for creativity, critique and persuasion, in the representation of social actors and events and in the evaluation of the consequences of Brexit. The paper focuses on the use and interaction of metaphors, metonymies, blending strategies, and cultural models in cartoons depicting the Brexit conundrum, from the perspective of Critical Metaphor Analysis (CMA) (Charteris-Black, 2011; Musolff, 2012) and Multimodal Critical Discourse Analysis (MCDS) (Machin, 2013). The case study adopts an integrated multifaceted framework in the analysis of a representative sample of cartoons selected from quality newspapers published in the UK. The aim is to reveal the synergistic interplay in: (a) the use of metaphors, metonymies, blending strategies, and cultural models in the depiction of social actors, phenomena and events; (b) the features of creativity in the expression of political commentary by professional cartoonists (novelty, recontextualization); and (c) the role of political cartoons in the critique and challenge of political power, by creating counter-narratives and acting as vehicles of persuasion.