Introducing Immunophilins. From Organ Transplantation to Plant Biology

Romano, Patrick G.N.; He, Zengyong; Luan, Sheng

doi:10.1104/pp.103.900108

Cited by 19 publications

(20 citation statements)

References 35 publications

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“…Both of these groups include enzymes that possess peptidyl-prolyl cis/trans isomerase activity (Marks 1996), which may facilitate protein folding (Matouschek et al 1995). Arabidopsis genome mining and proteomics studies have revealed 52 immunophilin genes, out of which six cyclophilins and 12 FKBPs have been predicted to be imported or have been identified in the chloroplast (Romano et al 2004a). Here we review the studies of the lumenal immunophilins in the function and assembly of PSII.…”

Section: Psb29-a Possible Candidate Regulating the Assembly Of Psii-lmentioning

confidence: 97%

Auxiliary proteins involved in the assembly and sustenance of photosystem II

et al. 2008

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Chloroplast proteins that regulate the biogenesis, performance and acclimation of the photosynthetic protein complexes are currently under intense research. Dozens, possibly even hundreds, of such proteins in the stroma, thylakoid membrane and the lumen assist the biogenesis and constant repair of the water splitting photosystem (PS) II complex. During the repair cycle, assistance is required at several levels including the degradation of photodamaged D1 protein, de novo synthesis, membrane insertion, folding of the nascent protein chains and the reassembly of released protein subunits and different co-factors into PSII in order to guarantee the maintenance of the PSII function. Here we review the present knowledge of the auxiliary proteins, which have been reported to be involved in the biogenesis and maintenance of PSII.

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Section: Psb29-a Possible Candidate Regulating the Assembly Of Psii-lmentioning

confidence: 97%

Auxiliary proteins involved in the assembly and sustenance of photosystem II

et al. 2008

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“…In Arabidopsis, the identification of 16 immunophilins (11 FKBPs and 5 CYPs) in the thylakoid lumen suggests that these foldases play important roles in the assembly and upkeep of protein complexes such as the two photosystems, residing at least in part in the thylakoid lumen [9,79,105] AtFKBP20-2 has a unique pair of cysteine residues at the C-terminus, found to be reduced by thioredoxin (Trx), which itself gets reduced by NADPH by the action of NADP-Trx reductase. AtFKBP20-2 has been shown to be essential for the accumulation of the photosystem II (PSII) supercomplex [106].…”

Section: Redox Regulation and Fkbpsmentioning

confidence: 99%

“…Surprisingly, the chloroplast harbors the largest number of FKBPs. Most of them are localized in the thylakoid lumen and are involved in photosynthetic protein-complex assembly and redox regulation [26,[76][77][78][79].…”

Section: Plant Fk506 Binding Proteins (Fkbps)mentioning

confidence: 99%

Plant immunophilins: a review of their structure-function relationship

Vasudevan

Gopalan

Kumar

et al. 2015

Biochimica et Biophysica Acta (BBA) - General Subjects

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Studies on the structure and function of plant immunophilins are important in understanding their role in plant biology. By reviewing the structural and functional properties of some immunophilins that represent the emerging area of research in plant biology, we hope to increase the interest of researchers in pursuing further research in this area. This article is part of a Special Issue entitled Proline-directed Foldases: Cell Signaling Catalysts and Drug Targets.

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“…However, not all single-and multiple-domain FKBPs own folding activity and, interestingly, many form distinct protein complexes with diverse functions. [3][4][5] …”

Section: Fk506-binding Proteins (Fkbps)mentioning

confidence: 99%