To solve the problem of vibration caused by unbalanced dynamic force and surface crack on a marine air conditioner frame, three types of optimally designed structures were developed, and the core components were simulated. Using the finite element software ANSYS Workbench, an analysis of the optimized structure strength was conducted, and the natural frequency and corresponding mode shapes of the marine air conditioner frame were obtained. By comparing modal analysis results with the entire structure under actual operating conditions, it was identified that the maximum/minimum natural frequency of the frame is significantly less than the excitation frequency of the marine air conditioner, indicating that the frame structure will not resonate under the excitation frequency. Meanwhile, strength analysis results demonstrated that the stress on the surface of the upper middle beam under the impact load is the largest, in which the maximum total deformation was approximately 20 mm; while the maximum total deformation was approximately 1.5 mm using the optimized structure design.