Introduction to a series of reviews on clinical platelet disorders

Lopez, Jose A.; Berliner, Nancy

doi:10.1182/blood-2017-04-773507

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…They are related either to a defect in platelet production, increased platelet destruction or consumption, abnormal pooling or eventually to mixed mechanisms ( Table 2 ). Thrombocytopenia can be acute or chronic, acquired or inherited as reviewed recently [ 69 ].…”

Section: Diseases Of Platelet Numbers In Humansmentioning

confidence: 99%

Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases

Josefsson

Vainchenker

James

2020

IJMS

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Blood platelets have important roles in haemostasis, where they quickly stop bleeding in response to vascular damage. They have also recognised functions in thrombosis, immunity, antimicrobal defense, cancer growth and metastasis, tumour angiogenesis, lymphangiogenesis, inflammatory diseases, wound healing, liver regeneration and neurodegeneration. Their brief life span in circulation is strictly controlled by intrinsic apoptosis, where the prosurvival Bcl-2 family protein, Bcl-xL, has a major role. Blood platelets are produced by large polyploid precursor cells, megakaryocytes, residing mainly in the bone marrow. Together with Mcl-1, Bcl-xL regulates megakaryocyte survival. This review describes megakaryocyte maturation and survival, platelet production, platelet life span and diseases of abnormal platelet number with a focus on the role of Bcl-xL during these processes.

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Section: Diseases Of Platelet Numbers In Humansmentioning

confidence: 99%

Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases

Josefsson

Vainchenker

James

2020

IJMS

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“…Platelets are the second most abundant cells in blood and play an important role in physiological functions like hemostasis, thrombosis, and wound healing. Platelets are involved in antimicrobial defence, cancer growth and metastasis, tumour angiogenesis, release of inflammatory mediators, and progression of various diseases [2] , [3] , [4]. In host defence, platelets release their granular contents to destroy the internalized pathogens.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress induced platelet apoptosis/activation: alleviation by purified curcumin via ASK1-JNK/p-38 pathway

Manikanta

Paul

Mahalingam

et al. 2022

Preprint

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Platelets are known for their indispensable role in haemostasis and thrombosis. During oxidative stress, alteration in platelet function contributes towards multiple health complications. To date, various synthesized compounds have shown antiplatelet activity however, their uses are still ambiguous as these compounds display multiple side effects. Commercially used curcumin is a mixture of curcumin, demethoxy curcumin and bisdemethoxy curcumin. Majority of the studies demonstrate the effect of crude curcumin lacking specific understanding on the effect of pure curcumin. Therefore, in this study, curcumin was purified from crude curcumin mixture and examined against oxidative stress-induced platelet apoptosis and activation. Purified curcumin restored the AAPH-induced platelet apoptotic markers like reactive oxygen species, intracellular calcium level, mitochondrial membrane potential, cardiolipin peroxidation, cytochrome c release from mitochondria to the cytosol, and phosphatidyl serine externalization. Further, it inhibited agonists-induced platelet activation and aggregation, demonstrating its antiplatelet activity. Western blot analysis confirms the protective effect of purified curcumin against oxidative stress-induced platelet apoptosis and activation via down regulation of MAPKs protein activation including ASK1, JNK, p-38. This suggests that purified curcumin could be a potential therapeutic bioactive molecule to treat oxidative stress-induced platelet activation, apoptosis, and associated complications.

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Blood cell-based drug delivery systems: A biomimetic platform for antibacterial therapy

Rong

Raza

Wang

et al. 2022

European Journal of Pharmaceutics and Biopharmaceutics

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Introduction to a series of reviews on clinical platelet disorders

Cited by 4 publications

References 12 publications

Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases

Regulation of Platelet Production and Life Span: Role of Bcl-xL and Potential Implications for Human Platelet Diseases

Oxidative stress induced platelet apoptosis/activation: alleviation by purified curcumin via ASK1-JNK/p-38 pathway

Blood cell-based drug delivery systems: A biomimetic platform for antibacterial therapy

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