Introduction to micro-analytical systems: bioanalytical and pharmaceutical applications

Huikko, Katri; Kostiainen, Risto; Kotiaho, Tapio

doi:10.1016/s0928-0987(03)00147-7

Cited by 144 publications

(88 citation statements)

References 148 publications

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“…The development of miniaturized ultra-thin-layer chromatography (UTLC) [10] in addition to the development of other miniaturized analytical methods [11] is currently a hot topic in analytical chemistry. The UTLC method combined with UV or diode-array detection (DAD) provides faster elution times (1-6 min), lower solvent consumption (1-4 ml), and lower detection limits than those obtained when using the conventional TLC or HPTLC methods [12].…”

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confidence: 99%

Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry

Salo

Salomies

Harju

et al. 2005

J. Am. Soc. Mass Spectrom.

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The feasibility of ultra thin-layer chromatography atmospheric pressure matrix-assisted laser desorption ionization mass spectrometry (UTLC-AP-MALDI-MS) has been studied in the analysis of small molecules. Because of a thinner adsorbent layer, the monolithic UTLC plates provide 10 -100 times better sensitivity in MALDI analysis than conventional high performance thin-layer chromatography (HPTLC) plates. The limits of detection down to a low picomole range are demonstrated by UTLC-AP-MALDI-MS. Other advantages of UTLC over HPTLC include faster separations and lower solvent consumption. The performances of AP-MALDI-MS and vacuum MALDI-MS have been compared in the analysis of small drug molecules directly from the UTLC plates. The desorption from the irregular surface of UTLC plates with an external AP-MALDI ion source combined with an ion trap instrument provides clearly less variation in measurements of m/z values when compared with a vacuum MALDI-time-of-flight (TOF) instrument. The performance of the UTLC-AP-MALDI-MS method has been applied successfully to the purity analysis of synthesis products produced by solid-phase parallel synthesis method. (J Am Soc Mass Spectrom 2005, 16, 906 -915)

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confidence: 99%

Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry

Salo

Salomies

Harju

et al. 2005

J. Am. Soc. Mass Spectrom.

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“…Micropumps are the key components of microfluidic systems with applications ranging from biological fluid handling to microelectric cooling [1]. The traditional valve micropump usually utilizes mechanical parts to achieve rectifying [2].…”

Section: Introductionmentioning

confidence: 99%

Mechanism of piezoelectric micropump with four flexible valves

Wei

Ren

2017

IOP Conf. Ser.: Mater. Sci. Eng.

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A micropump driven by electrochemically produced short-lived bubbles I V Uvarov, S S Lemekhov, A E Melenev et al. Abstract. A piezoelectric micropump with four flexible valves is proposed and its mechanism is researched. In the micropump chamber four asymmetric flexible valves are used to achieve single direction flow. The instantaneous velocities are analyzed and the peak input and output velocities are 0.14 m/s and 0.2 m/s respectively. The net flow rate is calculated, which is about 2.5×10-11m3/s. Due to the low operating frequency, flexible valves structure, no heat and no restriction on transport fluid type, this kind of micropump can be used for liquid transport and other biological sample containing DNA.

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“…[3][4][5] Laser technique is thus considered a faster alternative to conventional techniques such as wet chemical etching with photomask, lithography, electron beam writing, or photo-patterning in terms of rapid prototyping. 2,6 In fact, great progress has been made in fabrication of glass microchannels using lasers in the past decades. One common method is the use of laser ablation to remove material for microchannel fabrication.…”

Section: Introductionmentioning

confidence: 99%

Investigation on CO2 laser irradiation inducing glass strip peeling for microchannel formation

Wang

2012

Biomicrofluidics

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The study investigates the use of CO 2 laser to induce glass strip peeling off to form microchannels on soda lime gass substrate. The strip peeling exhibits a strong dependence on the energy deposition rate on the glass surface. In spite of the vast difference in the combination of laser power and scanning speed, when the ratio of the two makes the energy deposition rate in the range 3.0-6.0 J/(cm 2 s), the temperature rising inside glass will be above the strain point and reach the softening region of the glass. As a result, glass strip peeling is able to occur and form microchannels with dimensions of 20-40 lm in depth and 200-280 lm in width on the glass surface. Beyond this range, higher energy depsotion rate would lead to surface melting associated with solidification cracks and lower energy deposition rate causes the generation of fragment cracks.

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Introduction to micro-analytical systems: bioanalytical and pharmaceutical applications

Cited by 144 publications

References 148 publications

Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry

Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry

Mechanism of piezoelectric micropump with four flexible valves

Investigation on CO2 laser irradiation inducing glass strip peeling for microchannel formation

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