Introduction to Neuroimaging Research in Autism Spectrum Disorders

Barnea-Goraly, Naama; Marzelli, Matthew

doi:10.1007/978-1-4614-4788-7_46

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Genetic Underpinnings Of Asd1

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2015

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“…The following is a brief overview of some notable and reproducible findings in ASD (also see Table 1); additional comprehensive reviews are also available by other authors. 64,[90][91][92][93][94][95][96][97]…”

Section: Genetic Underpinnings Of Asdmentioning

confidence: 99%

Neuroimaging endophenotypes in autism spectrum disorder

Mahajan

Mostofsky

2015

CNS Spectr.

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder that has a strong genetic basis, and is heterogeneous in its etiopathogenesis and clinical presentation. Neuroimaging studies, in concert with neuropathological and clinical research, have been instrumental in delineating trajectories of development in children with ASD. Structural neuroimaging has revealed ASD to be a disorder with general and regional brain enlargement, especially in the frontotemporal cortices, while functional neuroimaging studies have highlighted diminished connectivity, especially between frontal-posterior regions. The diverse and specific neuroimaging findings may represent potential neuroendophenotypes, and may offer opportunities to further understand the etiopathogenesis of ASD, predict treatment response and lead to the development of new therapies.

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