Introduction to Traditional Herbal Medicines and their Study

Liu, Willow J. H.

doi:10.1002/9780470921340.ch1

Cited by 25 publications

(25 citation statements)

References 14 publications

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“…Regulatory guidelines include the identification of botanical origin, chemical profiles, and biological efficacy. 18 Although scientific data is lacking, medicinal food has occasionally been regarded as valuable and expensive due to its rarity. In the present study, we performed qualitative and quantitative analyses of P. lactiflora and P. obovata roots using colorimetry and HPLC paired with a UV photodiode array.…”

Section: Discussionmentioning

confidence: 99%

Differences in the Chemical Profiles and Biological Activities of Paeonia lactiflora and Paeonia obovata

Bae

Kim²,

Kim³

et al. 2015

Journal of Medicinal Food

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Paeonia lactiflora and P. obovata are perennial herbs, each root of which has been consumed as a major oriental medicine, Paeoniae Radix and a famous folk medicine, Mountain Paeony Root, respectively. Although morphological studies have been performed comparing these two plants, there is insufficient scientific evidence that characterizes the differences in their chemical profiles and biological activities. Hence, the present study was undertaken to compare these two medicinal foods using a high-performance liquid chromatography-diode-array detector (HPLC-DAD) analysis and a gastric ulcer model in mice. HPLC analysis employed to assess the nine components revealed that P. lactiflora exhibited higher contents of phenolic compounds than P. obovata. Although a monoterpene glycoside, 60 -O-acetylpaeoniflorin was identified in P. obovata, it was not detected in P. lactiflora. Multivariate statistical analysis for HPLC data revealed that the orthogonal projections to latent structure-discriminant analysis is more appropriate than principal component analysis for differentiating the two groups. Moreover, the 50% methanol P. lactiflora extract (PL) was more effective against experimental gastric ulcer than P. obovata extract (PO) in the HCl/ethanol-induced ulcer model. In addition, PL displayed higher 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and lower nitric oxide production in a murine macrophage cell line, RAW 264.7, than PO. The DPPH radical scavenging activity of PL was as high as that of the positive control, butylated hydroxytoluene, at a concentration of 25 lg/mL.

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Section: Discussionmentioning

confidence: 99%

Differences in the Chemical Profiles and Biological Activities of Paeonia lactiflora and Paeonia obovata

Bae

Kim²,

Kim³

et al. 2015

Journal of Medicinal Food

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“…Absorção acima de 300 nm indica a existência de um sistema conjugado longo. 35 Para amostras de café, estas regiões estão associadas às transições eletrô-nicas das moléculas de trigonelina, cafeína e ácidos clorogênicos.…”

Section: Resultsunclassified

Efeito do solvente na extração de ácidos clorogênicos, cafeína e trigonelina em Coffea arabica

Moreira¹,

Scheel²,

Hatumura³

et al. 2014

Quím. Nova

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SOLVENT EFFECTS ON EXTRACTION OF CHLOROGENIC ACIDS, CAFFEINE AND TRIGONELLINE IN Coffea arabica.In this research work the effects of four solvents and their mixtures on the extraction of chlorogenic acids, caffeine and trigonelline in crude extracts of four coffee cultivars, traditional red bourbon, IAPAR59, IPR101 and IPR108 cultivars, were investigated by UV spectrophotometry and UV spectra obtained from RP-HPLC-DAD. The experimental results and the principal component analysis of UV spectra showed that the effect of solvent extraction of the metabolites does not depend on cultivars, because the spectral characteristics are similar, but the concentrations are different. The UV and UV-DAD spectra for four simplex centroid design mixtures were also similar but the concentrations of caffeine, trigonelline and the chlorogenic acids are different and depend on the solvent used in the extraction.Keywords: fingerprint; mixture design; Coffea arabica. INTRODUÇÃOOs grãos do café contêm proteinas, lipidios, ácidos nucleicos, carboidratos, clorofila, carotenóides, enzimas e hormônios. Quando torrados, estes constituintes são destruidos ou podem ser transformados em uma grande variedade de novos compostos. 1 Os grãos do café verde também contém compostos biologicamente ativos como a cafeína, ácidos clorogenicos (ACG), trigonelina, entre outros. Estes metabólitos são alguns dos precursores do aroma do café. 2 A trigonelina é rapidamente decomposta na torra do café em muitos componentes voláteis, mas mesmo assim é encontrada no café torrado em concentrações mais baixas. 1 Os ACG são os principais compostos fenólicos encontrados no café, sendo ésteres de ácidos trans-cinâmico tais como, ácidos cafeico, ferúlico e p-cumárico com ácido quínico. 3 São metabólitos secundários de grande interesse econômico porque também contribuem na formação de pigmentos e sabor dos grãos do café, determinando assim a qualidade e aceitação da bebida. A cafeína, por ser o principal metabólito fisiologicamente ativo e o alcalóide quantitativamente mais importante do café, foi e ainda é o mais estudado desde a sua descoberta e identificação. 1 As duas variedades comerciais mais importantes de café são a Coffea arabica e a Coffea canephora syn. Coffea robusta, sendo C. arabica de qualidade superior. Por esta razão, vários trabalhos relatam métodos para discriminar as duas espécies. 4-9 Embora existam milhares de artigos na literatura sobre cafés defeituosos e não-defeituosos, 10,11 propriedades antioxidantes dos metabólitos, 12 os efeitos do café na saúde, 13-15 os efeitos da torrefação dos grãos de café, 12 a qualidade da bebida, 16-20 entre outros, poucos são os relatos na literatura sobre o efeito do solvente na extração de ácidos clorogênicos, cafeína e trigonelina, principalmente na variedade Coffea arabica.Nos programas de melhoramento genético do café o objetivo é desenvolver diferentes cultivares para promover ganhos na produtividade e também agregar características agronômicas de resistência às pragas e doenças. Por outro lado, a composição...

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“…Traditional Chinese Medicines (TCM) are documented for modern pharmacological characteristics in a recent book chapter. [47] Kue-chin-fu-ling-man (KBG) improved clinical symptoms of hypermenorrhea and dysmenorreha in 110 premenopausal women with uterine fibroids and fibroid shrinkage was observed in ~60% of the women. TCM relate fibroid formation to stagnated blood (“ yu zheng ”) accumulation.…”

Section: Herbals As a Therpetuic Drug Strategymentioning

confidence: 99%

Treatment for uterine fibroids: Searching for effective drug therapies

Taylor

Leppert

2012

Drug Discovery Today: Therapeutic Strategies

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Uterine fibroids are common reproductive-age benign tumors that contribute to severe morbidity and infertility. Cumulative incidence is 4 times higher in Africian-Americans compared to Caucasians and constitutes a major health disparity challenge. Fibroids are the leading indication for hysterectomy and their management averages $21 billion annually in the US. No long term minimally invasive therapies exist. Thus, promising drug therapies, their chemistry, pharmacology, and clinical efficacy, focusing first on innovative drug delivery approaches, are reviewed.

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Introduction to Traditional Herbal Medicines and their Study

Cited by 25 publications

References 14 publications

Differences in the Chemical Profiles and Biological Activities of Paeonia lactiflora and Paeonia obovata

Differences in the Chemical Profiles and Biological Activities of Paeonia lactiflora and Paeonia obovata

Efeito do solvente na extração de ácidos clorogênicos, cafeína e trigonelina em Coffea arabica

Treatment for uterine fibroids: Searching for effective drug therapies

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